TITLE

Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion

AUTHOR(S)
Cherrill, David A.; Stote, Robert M.; Birge, James R.; Singer, Irwin; Cherrill, D A; Stote, R M; Birge, J R; Singer, I
PUB. DATE
November 1975
SOURCE
Annals of Internal Medicine;Nov75, Vol. 83 Issue 5, p654
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
ACCESSION #
6967345

 

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