TITLE

Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density

AUTHOR(S)
Brattig, Norbert W.; Lepping, Bianca; Timmann, Christian; Büttner, Dietrich W.; Marfo, Yeboah; Hamelmann, Christoph; Horstmann, Rolf D.; Büttner, Dietrich W
PUB. DATE
April 2002
SOURCE
Journal of Infectious Diseases;4/15/2002, Vol. 185 Issue 8, p1148
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
The cellular immune response to Onchocerca volvulus antigen (OvAg) was studied in 551 persons exposed to O. volvulus transmission in a hyperendemic area of Ghana, West Africa. A whole-blood assay showed that, in response to a soluble O. volvulus extract, cell proliferation, as well as interleukin (IL)-5 and IL-13 concentrations in the supernatants, were high in cultures of blood from microfilaria (mf)-negative persons and significantly decreased with increasing mf counts of the donors. Only background concentrations of interferon (IFN)-gamma were found, and these did not correlate with mf counts. In response to a mitogen, cells from all persons strongly reacted with proliferation and secretion of all 3 cytokines studied. These findings show that the response of human peripheral blood cells to OvAg does not include significant IFN-gamma production; that mf negativity is associated with IL-5 and IL-13 production but not, as previously suggested, with IFN-gamma production; and that IL-5 and IL-13 production decreases with increasing mf density.
ACCESSION #
6435192

 

Related Articles

  • Cytokines Profile in Some Cameroonians with Onchocerca volvulus infection and the Relationship with their blood cells. Nmorsi, O. P. G.; Baleguel, N. P.; Che, J.; Isaac, C; Okonkwo, B. C // Archives of Applied Science Research;2012, Vol. 4 Issue 6, p2418 

    Onchocerca volvulus microfilariaemia was determined the skin tissues of 80 volunteers from Cameroon. The serum of these 80 volunteers and their 16 control counterparts were analysed for cytokines namely Interleukin (IL-) IL-1β, IL - 4, Tumor necrosis factor alpha (TNF-α), Interferon gamma...

  • Counting the cost of Africa's itch. Aldhous, Peter // New Scientist;4/15/95, Vol. 146 Issue 1973, p10 

    Reports on the World Bank and the World Health Organization's (WHO) search for funds to control a severe itch caused by the larvae of the worm Onchocerca volvulus which infect people living in the forests of equatorial Africa. Success of program to treat victims of a strain of O. volvulus that...

  • A randomized, double-blind, controlled trial of the effects of ivermectin at normal and high doses, given annually or three-monthly, against Onchocerca volvulus: ophthalmological results Fobi, Grace; Gardon, Jacques; Kamgno, Joseph; Aimard-Favennec, Laurence; Lafleur, Christian; Gardon-Wendel, Nathalie; Duke, Brian O.L.; Boussinesq, Michel // Transactions of the Royal Society of Tropical Medicine & Hygiene;Apr2005, Vol. 99 Issue 4, p279 

    Summary: A three-year randomized, controlled, double-blind trial was conducted in Cameroon to determine whether ivermectin, given at three-monthly intervals and/or at high doses (800μg/kg), had a greater effect on adult Onchocerca volvulus than standard doses (150μg/kg annually). As...

  • Can ivermectin mass treatments eliminate onchocerciasis in Africa? Winnen, M.; Plaisier, A.P.; Alley, E.S.; Nagelkerke, N.J.D.; van Oortmarssen, G.; Boatin, B.A.; Habbema, J.D.F. // Bulletin of the World Health Organization;2002, Vol. 80 Issue 5, p384 

    Objective To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community. Methods ONCHOSIM, a microsimulation model for onchocerciasis transmission, was used to explore the...

  • Distribution of the Blinding and Nonblinding strains of Onchocerca volvulus in Nigeria. Ogunrinade, Ade; Boakye, Daniel; Merriweather, Anthony; Unnasch, Thomas R. // Journal of Infectious Diseases;6/1/99, Vol. 179 Issue 6, p1577 

    Studies the distribution of the blinding and nonblinding strains of Onchocerca volvulus in Nigeria. Strain distribution; Classification of Onchocerca volvulus isolates on basis of hybridization; Characterization of different Onchocerca volvulus strains.

  • Early Human Infection with Onchocerca Volvulus Is Associated with and Enhanced Parasite-Specific Cellular Immune Response. Cooper, Philip J.; Nutman, Thomas B.; Mancero, Tamara; Espinel, Mauricio; Sandoval, Carlos; Lovato, Raquel; Guderian, Ronald H. // Journal of Infectious Diseases;6/1/2001, Vol. 183 Issue 11, p1662 

    Presents information on a study which examined the association between Onchocerca volvulus infection and cellular immune responses. Types of cellular immune responsiveness; Methodology; Results and discussion.

  • Immune responses directed against microfilariae correlate with severity of clinical onchodermatitis and treatment history. Ali, Magdi M.; Baraka, Omer Z.; AbdelRahman, Suzan I.; Sulaiman, Suad M.; Williams, Jeffrey F.; Homeida, Mamoun M.; Mackenzie, Charles D. // Journal of Infectious Diseases;2/15/2003, Vol. 187 Issue 4, p714 

    The induction of pathological changes in Onchocerca volvulus infections is directly related to the presence of the microfilarial stage of this filarial nematode. Patients with either of the 2 major forms of the clinical disease (i.e., asymptomatic/mild [n=12] and severe [n=16] dermatopathology)...

  • Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H. Meri, Taru; Jokiranta, T. Sakari; Hellwage, Jens; Bialonski, Alexandra; Zipfel, Peter F.; Meri, Seppo // Journal of Infectious Diseases;6/15/2002, Vol. 185 Issue 12, p1786 

    The filarial parasite Onchocerca volvulus is the causative agent of river blindness. The adult worms produce microfilariae (mf), which are responsible for the disease pathogenesis; mf activate the complement system, but the activation stops before the formation of terminal complement complexes....

  • Assessment Of The Epidemiology Of Onchocerca Volvulus After Treatment With Ivermectin In The Federal Capital Territory, Abuja, Nigeria. Eze, Jonathan; Malau, Matur Bernard // International Journal of Research & Reviews in Applied Sciences;2011, Vol. 7 Issue 3, p319 

    Study area: The study was conducted in the University of Abuja teaching hospital Gwagwalada, Abuja, from February 2009-June 2010. Methodology: five (5) Skin snips were randomly collected from various parts of the body of volunteered onchocercal patients visiting the hospital and incubated inside...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics