TITLE

Alkaline phosphatase: does it have a role in predicting hepatocellular carcinoma recurrence?

AUTHOR(S)
Yu, Ming-Chin; Chan, Kun-Ming; Lee, Chen-Fang; Lee, Yun-Shien; Eldeen, Firas; Chou, Hong-Shiue; Lee, Wei-Chen; Chen, Miin-Fu; Eldeen, Firas Zahr
PUB. DATE
August 2011
SOURCE
Journal of Gastrointestinal Surgery;Aug2011, Vol. 15 Issue 8, p1440
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Backgrounds: Surgical resection remains the first line of treatment for earlier stages of hepatocellular carcinoma (HCC), and it offers the best prognosis for long-term survival. Nevertheless, the recurrence rates after resection are still high in reports. Therefore, it is still essential to explore any potential prognostic factors to attain relatively longer-term survival of HCC patients.Materials and Methods: In the period from 1983 to 2005, 1,685 patients who underwent hepatectomy at Chang Gung Memorial hospital were enrolled in the study, and their clinicopathological data were retrospectively reviewed for survival analysis.Results: The 1-, 3-, 5-, and 10-year disease-free survival (DFS) rates in this series were 60.3%, 39.7%, 31.3%, and 24.0%, respectively, whereas the 1-, 3-, 5-, and 10-year overall survival (OS) rates were 80.1%, 59.1%, 46.6%, and 27.7%, respectively. Gross vascular invasion, tumor status, lymph node involvement, satellite lesion, positive surgical margin, alkaline phosphatase (ALP), albumin, presence of cirrhosis, and Child grade B or C were independent prognostic factors for prediction of DFS; while α-fetoprotein, ALP, surgical factors, including complications, blood transfusion, positive resection margin, and tumor characters including tumor status, vascular invasion, and lack of tumor encapsulation were found to be independent predicting factors for OS, as determined by Cox regression analysis. Interestingly, we found that preoperative level of ALP was one of the most important independent predictors of recurrence, even more important that α-fetoprotein (AFP) as we noticed that elevation of ALP above (82 U/L) predicted poor prognosis in patients where AFP levels was less than 66 ng/ml. It is worth to mention that ALP was statistically related to other liver function tests, but not tumor characters by hierarchical clustering; which means that we were able to correlate ALP with prognosis statistically, but not with pathological criteria of the tumor; to elucidate these finding, further basic science research is required.Conclusion: ALP among liver function tests, in addition to other tumor characters were independent factors for DFS and OS; our results suggest that preoperative ALP levels could be utilized to monitor and predict recurrence in high risk HCC patients.
ACCESSION #
63235057

 

Related Articles

  • Clinicopathological characteristics and prognostic factors in young patients after hepatectomy for hepatocellular carcinoma. Shimada, Shingo; Kamiyama, Toshiya; Yokoo, Hideki; Wakayama, Kenji; Tsuruga, Yosuke; Kakisaka, Tatsuhiko; Kamachi, Hirofumi; Taketomi, Akinobu // World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, p1 

    Background: The aim of this study was to analyze the clinicopathological characteristics and the prognostic factors for survival and recurrence of young patients who had undergone hepatectomy for hepatocellular carcinoma. Methods: Between 1990 and 2010, 31 patients aged 40 years or younger...

  • Laparoscopic surgery minimizes the release of circulating tumor cells compared to open surgery for hepatocellular carcinoma. Li, Wenda; Zhou, Xue; Huang, ZeJian; Zhang, Hongwei; Zhang, Lei; Shang, Changzhen; Chen, Yajin // Surgical Endoscopy;Nov2015, Vol. 29 Issue 11, p3146 

    Background: The aim of this study was to determine whether tumor manipulation enhances cancer cell release from the primary tumor in HCC patients and which surgical approach, open surgery or laparoscopic resection, is superior with respect to preventing tumor cells from scattering...

  • Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging. Zhang, Guo-Yi; Huang, Ying; Hu, Xue-Feng; Chen, Xiang-Ping; Xu, Tao; Liu, Li-Zhi; Wei, Wei-Hong; Huang, Guo-Sen; Zhou, Miao-Miao; Huang, Ze-Li; Wang, Yue-Jian // BioMed Research International;3/26/2015, Vol. 2015, p1 

    Purpose. To subclassify parapharyngeal extension in nasopharyngeal carcinoma (NPC) and investigate its prognostic value and staging categories based on magnetic resonance imaging (MRI). Methods and Materials. Data from 1504 consecutive NPC patients treated with definitive-intent radiotherapy...

  • In Hepatocellular Carcinomas, any Proportion of Poorly Differentiated Components is Associated with Poor Prognosis After Hepatectomy. Sasaki, Kazunari; Matsuda, Masamichi; Ohkura, Yu; Kawamura, Yusuke; Inoue, Masafumi; Hashimoto, Masaji; Ikeda, Kenji; Kumada, Hiromitsu; Watanabe, Goro // World Journal of Surgery;May2014, Vol. 38 Issue 5, p1147 

    Background: Hepatocellular carcinoma (HCC) often consists of various differentiation components in a single tumor. However, the categorization of histologic grade in hepatectomy for those tumors has not been standardized. Some studies have determined the differentiation grade of the tumor...

  • Research for Mediastinal Lymph Node Disection Style of Stage Ib Upper Lobe Non-small Cell Lung Cancer. Wenli WANG; Feng MAO; Yang SHEN-TU; Yunqing MEI // Chinese Journal of Lung Cancer;Nov2013, Vol. 16 Issue 11, p584 

    Background and objective Lymphatic metastasis is the most important way for the spread of lung cancer and is one of the important factors affecting the prognosis. Existing studies showed that compared to middle or lower lobe NSCLC, upper lobe non-small cell lung cancer (NSCLC) has a higher...

  • Survival After Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-Analysis. Chen, Jinggui; Huang, Kai; Wu, Jianghong; Zhu, Huiyan; Shi, Yingqiang; Wang, Yanong; Zhao, Guangfa // Digestive Diseases & Sciences;Jun2011, Vol. 56 Issue 6, p1626 

    Background and Objectives: To compare the effect on survival of anatomic resection (AR) versus nonanatomic resection (NAR) in patients with hepatocellular carcinoma (HCC) from all published comparative studies in the literature. Methods: Databases, including Pubmed, Embase, the Cochrane Library,...

  • Family history of hepatocellulcar carcinoma is not associated with its patients' prognosis after hepatectomy. Jia Huang; Yaojun Zhang; Meixian Chen; Junting Huang; Li Xu; Minshan Chen // World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, p1 

    Background Family history of liver cancer is a major risk factor for hepatocellular carcinoma (HCC). In this study, we investigated the prognosis of patients with HCC with or without family history. Methods Data for 1,313 patients who underwent hepatectomy as initial treatment for HCC between...

  • Expression and Significance of Snail and Claudin-3 in Non-small Cell Lung Cancer. Juan Li; Yuan Tu; Lili Jiang; Huan Xu; Shangfu Zhang // Chinese Journal of Lung Cancer;Oct2012, Vol. 15 Issue 10, p583 

    Background and objective Epithelial-mesenchymal transition (EMT) is considered to be one of the major molecular mechanisms inducing tumor invasion and metastasis. The loss of epithelial cell polarity is a hallmark of the EMT process. Epithelial markers such as Claudin are lost in EMT. Snail is a...

  • Circulating Tumor Cells and Recurrence After Primary Systemic Therapy in Stage III Inflammatory Breast Cancer. Hall, Carolyn S.; Karhade, Mandar; Laubacher, Barbara A.; Kuerer, Henry M.; Krishnamurthy, Savitri; DeSnyder, Sarah; Anderson, Amber E.; Valero, Vicente; Ueno, Naoto T.; Yisheng Li; Xiao Su; Lucci, Anthony; Li, Yisheng; Su, Xiao // JNCI: Journal of the National Cancer Institute;Nov2015, Vol. 107 Issue 11, p1 

    Inflammatory breast cancer (IBC) is rare and aggressive, with poor survival. While circulating tumor cells (CTCs) predict outcome in non-IBC patients, little data exists regarding their prognostic significance in IBC. This prospective study analyzed blood samples for CTCs from 63 stage III IBC...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics