TITLE

Dietary nitrate, nitric oxide, and restenosis

AUTHOR(S)
Cooke, John P.; Ghebremariam, Yohannes T.
PUB. DATE
April 2011
SOURCE
Journal of Clinical Investigation;Apr2011, Vol. 121 Issue 4, p1258
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Endothelium-derived NO controls the contractility and growth state of the underlying vascular smooth muscle cells and regulates the interaction of the vessel wall with circulating blood elements. Acute injury of the vessel wall denudes the endothelial lining, removing homeostatic regulation and precipitating a wave of events leading to myointimal hyperplasia. In this issue of the JCI, Alef and colleagues provide evidence that in the injured vessel wall, the disruption of the NOS pathway is countered by induction of xanthine oxidoreductase, an enzyme capable of producing NO from nitrite. In addition, they link low dietary nitrite levels to increased severity of myointimal hyperplasia following vessel injury in mice.
ACCESSION #
60270786

 

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