TITLE

Suture-free anastomosis of the colon. Experimental comparison of two cyanoacrylate adhesives

AUTHOR(S)
Paral, Jiri; Subrt, Zdenek; Lochman, Petr; Klein, Leo; Hadzi-Nikolov, Dimitar; Turek, Zdenek; Vejbera, Martin
PUB. DATE
March 2011
SOURCE
Journal of Gastrointestinal Surgery;Mar2011, Vol. 15 Issue 3, p451
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: We explored the potential of two cyanoacrylate tissue adhesives for constructing colonic anastomoses.Method: The study involved 12 female domestic pigs. The animals were divided into two equal groups. In both groups, the sigmoid colon was transected. An intestinal anastomosis was constructed with a modified circular stapler (all staples were withdrawn) and cyanoacrylate tissue adhesives. Glubran 2 was used in group A and Dermabond was applied in group B. Fourteen days after the first operation, a follow-up surgery was performed in both groups. The glued section of the colon was resected, processed with the standard paraffin technique and stained with haematoxylin-eosin. The finished specimens were examined under light microscopy. Assessments were made for the presence of fibroblasts, neutrophils, giant polynuclear cells, neovascularisation and collagen deposits. Adhesions, anastomotic dehiscence, peri-anastomotic inflammation and intestinal healing were assessed peri-operatively.Results: All anastomoses in group A healed with no signs of pathology. In group B, fibrotic adhesions and stenoses tended to occur in areas surrounding the anastomoses. Histological examinations confirmed increased fibrosis.Conclusion: The tissue adhesive Glubran 2 appears to be (under experimental conditions) a promising synthetic adhesive for colonic anastomosis construction; conversely, the tissue adhesive Dermabond was unsuitable for suture-free anastomosis construction.
ACCESSION #
58606536

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics