Analgesia: Pain control at the periphery

Kingwell, Katie
November 2010
Nature Reviews Neuroscience;Nov2010, Vol. 11 Issue 11, p732
Academic Journal
journal article
A small molecule that increases endocannabinoid signalling at sensory nerve terminals enhances analgesia.


Related Articles

  • Selective axonal and glial distribution of monoacylglycerol lipase immunoreactivity in the superficial spinal dorsal horn of rodents. Dócs, Klaudia; Hegyi, Zoltán; Holló, Krisztina; Kis, Gréta; Hegedűs, Krisztina; Antal, Miklós // Brain Structure & Function;Sep2015, Vol. 220 Issue 5, p2625 

    The importance of 2-AG-mediated endogenous cannabinoid signaling in spinal pain control has recently been well substantiated. Although the degradation of 2-AG seems to be essential in cannabinoid-mediated spinal nociceptive information processing, no experimental data are available about the...

  • Local administration of Δ[sup 9] -tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action. Ko, M.-C.; Woods, James H. // Psychopharmacology;1999, Vol. 143 Issue 3, p322 

    Abstract Rationale: Cannabinoids can reduce nociceptive responses by acting on peripheral cannabinoid receptors in rodents. Objectives: The study was conducted to evaluate the hypothesis that local administration of change[sup 9]-tetrahydrocannabinol (change[sup 9]-THC) can attenuate...

  • Analgesics: Pain control at the periphery. Kingwell, Katie // Nature Reviews Drug Discovery;Nov2010, Vol. 9 Issue 11, p839 

    The article discusses research being done on pain treatment without the risk of side effects from cannabinoid (CB) receptors in the periphery. It references the study "Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism" by J. R. Clapper and colleagues in the...

  • Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes. Sekerková, Gabriella; Watanabe, Masahiko; Martina, Marco; Mugnaini, Enrico // Brain Structure & Function;Mar2014, Vol. 219 Issue 2, p719 

    Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic...

  • Chemokine Network in the Nervous System: A New Target for Pain Relief. Gosselin, R. D.; Dansereau, M. A.; Pohl, M.; Kitabgi, P.; Beaudet, N.; Sarret, P.; Parsadaniantz, S. Mélik // Current Medicinal Chemistry;2008, Vol. 15 Issue 27, p2866 

    Physical insults including but not limited to nerve damage, inflammation, visceral pathologies and cancer generate long lasting pain commonly referred as chronic pain. Recently, members of the chemokine family and their receptors emerged as key modulators in nociceptive influx transmission in...

  • Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Agarwal, Nitin; Pacher, Pal; Tegeder, Irmgard; Amaya, Fumimasa; Constantin, Cristina E; Brenner, Gary J; Rubino, Tiziana; Michalski, Christoph W; Marsicano, Giovanni; Monory, Krisztina; Mackie, Ken; Marian, Claudiu; Batkai, Sandor; Parolaro, Daniela; Fischer, Michael J; Reeh, Peter; Kunos, George; Kress, Michaela; Lutz, Beat; Woolf, Clifford J // Nature Neuroscience;Jul2007, Vol. 10 Issue 7, p870 

    Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory...

  • Evidence for neural progenitor cells in the human adult enteric nervous system. Azan, Gaetano; Low, Walter; Wendelschafer-Crabb, Gwen; Ikramuddin, Sayeed; Kennedy, William // Cell & Tissue Research;May2011, Vol. 344 Issue 2, p217 

    Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult...

  • Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model. Jung, Yookyung; Ng, Joanna H.; Keating, Cameron P.; Senthil-Kumar, Prabhu; Zhao, Jie; Randolph, Mark A.; Winograd, Jonathan M.; Evans, Conor L. // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Peripheral nerve injury (PNI), a common injury in both the civilian and military arenas, is usually associated with high healthcare costs and with patients enduring slow recovery times, diminished quality of life, and potential long-term disability. Patients with PNI typically undergo complex...

  • Ãœst ekstremite cerrahisinde uygulanan brakial pleksus sinir bloÄŸu deneyimlerimiz. Çelik, Feyzi; Tüfek, Adnan; Yıldırım, Zeynep B.; Tokgöz, Orhan; Karaman, Haktan; Alemdar, Celil; Çiftçi, Taner; Uslukaya, Ömer; Kavak, Gönül Ölmez // Dicle Medical Journal / Dicle Tip Dergisi;2012, Vol. 39 Issue 1, p31 

    Objective: Peripheral nerve blocks are usually used either alone or along with general anesthesia for postoperative analgesia. We also aimed to present the results and experiences. Materials and methods: This retrospective study was conducted to scan the files of patients who underwent...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics