TITLE

Detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid

AUTHOR(S)
Potter, M.A.; Morris, R.G.; Ferguson, A.; Wyllie, A. H.
PUB. DATE
April 1998
SOURCE
JNCI: Journal of the National Cancer Institute;04/15/98, Vol. 90 Issue 8, p623
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Presents information on the detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid. Percentage of overall five-year survival rate for colorectal cancer; Details on the study conducted; Observations made in study.
ACCESSION #
499972

 

Related Articles

  • Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer. Steine, Eveline J.; Ehrich, Mathias; Bell, George W.; Raj, Arjun; Reddy, Seshamma; van Oudenaarden, Alexander; Jaenisch, Rudolf; Linhart, Heinz G. // Journal of Clinical Investigation;May2011, Vol. 121 Issue 5, p1748 

    Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated aberrant DNA methylation is targeted to specific genomic regions, whether...

  • Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Win, A. K.; Dowty, J. G.; English, D. R.; Campbell, P. T.; Young, J. P.; Winship, I.; Macrae, F. A.; Lipton, L.; Parry, S.; Young, G. P.; Buchanan, D. D.; Martínez, M. E.; Jacobs, E. T.; Ahnen, D. J.; Haile, R. W.; Casey, G.; Baron, J. A.; Lindor, N. M; Thibodeau, S. N.; Newcomb, P. A. // British Journal of Cancer;6/20/2011, Vol. 105 Issue 1, p162 

    Background: Carriers of germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), but the modifiers of this risk are not well established. We estimated an association between body mass index (BMI) in early adulthood and subsequent risk of CRC...

  • What is most important to patients when deciding about colorectal screening? Imaeda, Avlin; Bender, Danielle; Fraenkel, Liana // JGIM: Journal of General Internal Medicine;Jul2010, Vol. 25 Issue 7, p688 

    Background: Colorectal cancer (CRC) screening can be administered through tests with varied characteristics and is a preference-sensitive decision.Objective: To assess patient experiences with a Maximum Differences Scaling (MDS) tool for eliciting values about CRC...

  • Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer. Mrkonjic, M.; Chappell, E.; Pethe, V. V.; Manno, M.; Daftary, D.; Greenwood, C. M.; Gallinger, S.; Zanke, B. W.; Knight, J. A.; Bapat, B. // British Journal of Cancer;6/16/2009, Vol. 100 Issue 12, p1966 

    ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in...

  • Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. Yangyan Jiang; Wenlu Li; Xin He; Hongbo Zhang; Fangzhen Jiang; Zhigang Chen; Jiang, Yangyan; Li, Wenlu; He, Xin; Zhang, Hongbo; Jiang, Fangzhen; Chen, Zhigang // BMC Cancer;1/12/2016, Vol. 16, p1 

    Background: Lgr5 has recently been identified as a reliable biomarker of cancer stem cells (CSCs) in colorectal cancer (CRC); however, its prognostic value is still controversial.Methods: We searched PubMed, Web of Science, and Wanfang databases with identical...

  • Extracolonic findings at virtual colonoscopy: an important consideration in asymptomatic colorectal cancer screening. Kimberly, James R.; Phillips, Kim C.; Santago, Pete; Perumpillichira, James; Bechtold, Robert; Pineau, Benoit; Vining, David; Bloomfeld, Richard S. // JGIM: Journal of General Internal Medicine;Jan2009, Vol. 24 Issue 1, p69 

    Background: Virtual colonoscopy has been evaluated for use as a colorectal cancer screening tool, and in prior studies, it has been estimated that the evaluation of extra-colonic findings adds $28-$34 per patient studied.Methods: As an ancillary study to a prospective...

  • Induction of Cyclooxygenase-2 and Invasiveness by Transforming Growth Factor-β1 in Immortalized Mouse Colonocytes Expressing Oncogenic Ras Roman, Christopher D.; Morrow, Jason; Whitehead, Robert; Beauchamp, R. Daniel // Journal of Gastrointestinal Surgery;May2002, Vol. 6 Issue 3, p304 

    Cyclooxygenase-2 (COX-2) expression appears to be important in colorectal carcinogenesis. Elevated COX-2 expression and activity have been observed in several different transformed cell types. Prior studies implicating involvement of the Ras oncogene and growth factors on COX-2 expression were...

  • A culturally tailored navigator program for colorectal cancer screening in a community health center: a randomized, controlled trial. Percac-Lima, Sanja; Grant, Richard; Green, Alexander; Ashburner, Jeffrey; Gamba, Gloria; Oo, Sarah; Richter, James; Atlas, Steven; Grant, Richard W; Green, Alexander R; Ashburner, Jeffrey M; Richter, James M; Atlas, Steven J // JGIM: Journal of General Internal Medicine;Feb2009, Vol. 24 Issue 2, p211 

    Background: Minority racial/ethnic groups have low colorectal cancer (CRC) screening rates.Objective: To evaluate a culturally tailored intervention to increase CRC screening, primarily using colonoscopy, among low income and non-English speaking patients.Design:...

  • Favorable toxicity profile of raltitrexed in elderly patients treated for colorectal cancer: a case series. Franchi, F.; Pastore, C.; Caporale, A.; Fabiani, O.; Rossi, L.; Seminara, P. // Gerontology;Sep/Oct2003, Vol. 49 Issue 5, p324 

    Background: Age-related physiological changes may lead to an increased toxicity of chemotherapy in the elderly, thus making tumor treatment difficult in this increasing subset of patients.Objective: Since many trials claimed a favorable therapeutic index with...

  • Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver. Stagg, Robert J.; Lewis, Brian J.; Friedman, Michael A.; Ignoffo, Robert J.; Hohn, David C.; Stagg, R J; Lewis, B J; Friedman, M A; Ignoffo, R J; Hohn, D C // Annals of Internal Medicine;May84, Vol. 100 Issue 5, p736 

    Hepatic metastases of colorectal origin are resistant to radiation and immunotherapy. Traditional intravenous chemotherapy produces responses in 10% to 30% of patients, and surgical resection is feasible in approximately 20% of patients who have a solitary or unilobar lesion. Infusion of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics