Factor VIIa treatment of DIC as a clinical manifestation of amniotic fluid embolism in a patient with fetal demise

Kahyaoglu, Inci; Kahyaoglu, Serkan; Mollamahmutoglu, Leyla
July 2009
Archives of Gynecology & Obstetrics;Jul2009, Vol. 280 Issue 1, p127
Academic Journal
journal article
Introduction: A pregnant patient, with term intrauterine fetal demise, who developed cardiopulmonary arrest during labor, followed by disseminated intravascular coagulation (DIC) secondary to amniotic fluid embolism (AFE) that was treated with Recombinant Factor VIIa, is presented.Case Report: A 22-year-old Turkish woman was admitted to our antenatal clinic at 39 weeks 6 days of gestation with a complaint of decreased fetal movements for the previous 3 days. Shortly after presentation, she was noted to have circumoral cyanosis with shortness of breath and sudden loss of consciousness. After a 3,220 g macerated male fetus was delivered, persistent bleeding occurred in the mother and was managed with Recombinant Factor VIIa at a dose of 90 mcg/kg. She died 8 days after the admission due to multiple organ failure.Conclusion: Recombinant Factor VIIa may be a treatment option for hemorrhage in patients with DIC related to AFE.


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