Genetic influences on type 2 diabetes and metabolic syndrome related quantitative traits in Mauritius

Jowett, Jeremy B.; Diego, Vincent P.; Kotea, Navaratnam; Kowlessur, Sudhir; Chitson, Pierrot; Dyer, Thomas D.; Zimmet, Paul; Blangero, John
February 2009
Twin Research & Human Genetics;Feb2009, Vol. 12 Issue 1, p44
Academic Journal
journal article
Epidemiological studies report a high prevalence of type 2 diabetes and metabolic syndrome in the island nation of Mauritius. The Mauritius Family Study was initiated to examine heritable factors that contribute to these high rates of prevalence and consists of 400 individuals in 24 large extended multigenerational pedigrees. Anthropometric and biochemical measurements relating to the metabolic syndrome were undertaken in addition to family and lifestyle based information for each individual. Variance components methods were used to determine the heritability of the type 2 diabetes and metabolic syndrome related quantitative traits. The cohort was made up of 218 females (55%) and 182 males with 22% diagnosed with type 2 diabetes and a further 30% having impaired glucose tolerance or impaired fasting glucose. Notably BMI was not significantly increased in those with type 2 diabetes (P= .12), however a significant increase in waist circumference was observed in these groups (P= .02). The heritable proportion of trait variance was substantial and greater than values previously published for hip circumference, LDL and total cholesterol, diastolic and systolic blood pressure and serum creatinine. Height, weight and BMI heritabilities were all in the upper range of those previously reported. The phenotypic characteristics of the Mauritius family cohort are similar to those previously reported in the Mauritian population with a high observed prevalence rate of type 2 diabetes. A high heritability for key type 2 diabetes and metabolic syndrome related phenotypes (range 0.23 to 0.68), suggest the cohort will have utility in identifying genes that influence these quantitative traits.


Related Articles

  • Predicting adult metabolic syndrome from childhood body mass index: follow-up of the New Delhi birth cohort. Sachdev, H. P. S.; Osmond, C.; Fall, C. H. D.; Lakshmy, R.; Ramji, S.; Biswas, S. K. Dey; Prabhakaran, D.; Tandon, N.; Reddy, K. S.; Barker, D. J. P.; Bhargava, S. K. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Oct2009, Vol. 94 Issue 10, p6 

    Objectives: To assess whether serial measurements of childhood body mass index (BMI) give clinically useful predictions of the risk of developing adult metabolic syndrome and impaired glucose tolerance or type 2 diabetes. Design/setting: Follow-up of a community-based birth cohort in Delhi,...

  • The relative importance of modifiable potential risk factors of type 2 diabetes: a meta-analysis of two cohorts. Laaksonen, Maarit; Knekt, Paul; Rissanen, Harri; Härkänen, Tommi; Virtala, Esa; Marniemi, Jukka; Aromaa, Arpo; Heliövaara, Markku; Reunanen, Antti // European Journal of Epidemiology;Feb2010, Vol. 25 Issue 2, p115 

    Lifestyle factors predict type 2 diabetes occurrence, but their effect in high- and low-risk populations is poorly known. This study determines the prediction of low-risk lifestyle on type 2 diabetes in those with and without metabolic syndrome in a pooled sample of two representative Finnish...

  • The prevalence of metabolic syndrome and its predominant components among pre-and postmenopausal Ghanaian women. Arthur, Fareed Kow Nanse; Frimpong, Michael Adu; Yeboah, James Osei; Mensah, Faustina Obu; Owusu, Lawrence // BMC Research Notes;2013, Vol. 6 Issue 1, p1 

    Background Metabolic Syndrome (MetS) is a clump of risk factors for development of type 2 diabetes mellitus and cardiovascular diseases. Menopause and age are thought to predispose women to the development of metabolic syndrome. This study aimed to estimate the prevalence of MetS and identify...

  • Physical activity and risk of Metabolic Syndrome in an urban Mexican cohort. Méndez-Hernández, Pablo; Flores, Yvonne; Siani, Carole; Lamure, Michel; Dosamantes-Carrasco, L. Darina; Halley-Castillo, Elizabeth; Huitrón, Gerardo; Talavera, Juan O.; Gallegos-Carrillo, Katia; Salmerón, Jorge // BMC Public Health;2009, Vol. 9 Issue 1, p276 

    Background: In the Mexican population metabolic syndrome (MS) is highly prevalent. It is well documented that regular physical activity (PA) prevents coronary diseases, type 2 diabetes and MS. Most studies of PA have focused on moderate-vigorous leisure-time activity, because it involves higher...

  • Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis. Fenger, Mogens; Linneberg, Allan; Werge, Thomas; Jørgensen, Torben // BMC Genetics;2008, Vol. 9, Special section p1 

    Background: Biological systems are interacting, molecular networks in which genetic variation contributes to phenotypic heterogeneity. This heterogeneity is traditionally modelled as a dichotomous trait (e.g. affected vs. non-affected). This is far too simplistic considering the complexity and...

  • Genetic Predisposition for Type 2 Diabetes, but Not for Overweight/Obesity, Is Associated with a Restricted Adipogenesis. Arner, Peter; Arner, Erik; Hammarstedt, Ann; Smith, Ulf // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    Background: Development of Type 2 diabetes, like obesity, is promoted by a genetic predisposition. Although several genetic variants have been identified they only account for a small proportion of risk. We have asked if genetic risk is associated with abnormalities in storing excess lipids in...

  • Retinol Binding Protein 4 (RBP4) Levels Are Associated with Markers of Lipid Metabolism and Insulin Resistance in a British Cohort. Bouatia-Naji, Nabila; Semple, Robert K.; Luan, Jian'an; Burling, Keith; Loos, Ruth J.; O'Rahilly, Stephen; Wareham, Nicholas J. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA251 

    Retinol binding protein 4 (RBP4) is an adipokine that is up-regulated in the absence of GLUT4, and that increases liver and muscle insulin resistance in mice. In humans, high plasma levels of RBP4 have been correlated with several features of the metabolic syndrome in selected lean, obese or...

  • Leisure-Time Physical Activity and the Metabolic Syndrome in the Finnish Diabetes Prevention Study. Ilanne-Parikka, Pirjo; Laaksonen, David E.; Eriksson, Johan G.; Lakka, Timo A.; Lindström, Jaana; Peltonen, Markku; Aunola, Sirkka; Keinänen-Kiukaanniemi, Sirkka; Uusitupa, Matti; Tuomilehto, Jaakko // Diabetes Care;Jul2010, Vol. 33 Issue 7, p1610 

    OBJECTIVE -- To assess the effects of leisure-time physical activity (LTPA) and resistance training on metabolic syndrome (MetS) and its components in a post hoc analysis of the Finnish Diabetes Prevention Study, a randomized controlled lifestyle counseling trial. RESEARCH DESIGN AND...

  • Sindromul metabolic ÅŸi riscul de boli cardiovasculare într-o circumscripÈ›ie rurală din judeÈ›ul Bacău. DIAA, Alamir; POPA, Elena; BACUSCA, Agnes; TRAIAN, Maria Gabriela; PETROVANU, Rodica; COMAN, Adorata Elena // Romanian Journal of Medical Practice;2014, Vol. 9 Issue 3, p142 

    Aim. This study is aimed at obtaining an accurate statistical estimates of morbi-mortality data of patients with the metabolic syndrome, in a rural population (Pancesti village). Material and methods. Patients (615 cases) were selected after IDF criteria of metabolic syndrome diagnosis. Group I...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics