Sex-related differences in gene expression in salivary glands of BALB/c mice

Treister, N. S.; Richards, S. M.; Lombardi, M. J.; Rowley, P.; Jensen, R. V.; Sullivan, D. A.
February 2005
Journal of Dental Research;Feb2005, Vol. 84 Issue 2, p160
Academic Journal
journal article
Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.


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