TITLE

Association between asthma and serum adiponectin concentration in women

AUTHOR(S)
Sood, A.; Cui, X.; Qualls, C.; Beckett, W. S.; Gross, M. D.; Steffes, M. W.; Smith, L. J.; Jacobs Jr, D. H.; Jacobs, D R Jr
PUB. DATE
October 2008
SOURCE
Thorax;Oct2008, Vol. 63 Issue 10, p877
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma, particularly in women and in premenopausal women.Methods: A cross-sectional analysis was performed of 2890 eligible subjects at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort and its YALTA ancillary study who had either current asthma or never asthma at that evaluation. Obesity was defined as body mass index (BMI) >or=30 kg/m(2). Multivariable logistic regression analysis was performed with current asthma status as the dependent variable.Results: Women, but not men, with current asthma had a lower mean unadjusted serum adiponectin concentration than those with never asthma (p<0.001; p for sex interaction <0.001). Similarly, current asthma was related to obesity only in women (OR 3.31, 95% CI 2.00 to 5.46, p for sex interaction = 0.004); this association was little affected by adjusting for serum adiponectin. The prevalence of current asthma in premenopausal women was reduced in the highest compared with the lowest tertile of serum adiponectin concentration (OR 0.46, 95% CI 0.26 to 0.84, p = 0.03), after adjusting for BMI. However, the interaction between serum adiponectin concentration and BMI category on current asthma status was not significant in premenopausal women or women overall.Conclusions: A high serum adiponectin concentration may protect against current asthma in premenopausal women but does not explain the association between asthma and adiposity.
ACCESSION #
35024636

 

Related Articles

  • RESEARCH BRIEFS: Low antioxidant levels linked to asthma.  // GP: General Practitioner;2/16/2004, p11 

    U.S. researchers analyzed data on 4,093 children aged six to 17 years and found that those with the highest serum vitamin C levels were a third less likely to develop asthma than those with the lowest levels.

  • Fatigue and optimal conditions for short-term work capacity. MacIntosh, Brian R.; Svedahl, Krista; Kim, Minhan // European Journal of Applied Physiology;Aug2004, Vol. 92 Issue 4/5, p369 

    There is an optimal load and corresponding velocity at which peak power output occurs. It is reasonable to expect that these conditions will change as a result of fatigue during 30 s of all-out cycling. This study evaluated optimal velocity after 30 s of maximal isokinetic cycle ergometer...

  • Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia Lien, Yung-Chang; Hsieh, Chih-Cheng; Wu, Yu-Chung; Hsu, Han-Shui; Hsu, Wen-Hu; Wang, Liang-Shun; Huang, Min-Hsiung; Huang, Biing-Shiun // Journal of Gastrointestinal Surgery;Dec2004, Vol. 8 Issue 8, p1041 

    Among patients with adenocarcinoma of the gastric cardia, we noted that patients with higher preoperative serum albumin levels appeared to survive longer than patients with lower levels. Thus, we evaluated serum albumin as a prognostic factor for patient survival. From 1987 to 1997, 314 patients...

  • Effect of TCN2 776C>G on vitamin B12 cellular availability in end-stage renal disease patients. Födinger, Manuela; Veitl, Mario; Skoupy, Sonja; Wojcik, Jadwiga; Röhrer, Claudia; Hagen, Wolfgang; Puttinger, Heidi; Hauser, Anna-Christine; Vychytil, Andreas; Sunder-Plassmann, Gere // Kidney International;Sep2003, Vol. 64 Issue 3, p1095 

    Effect of TCN2 776C>G on vitamin B12 cellular availability in end-stage renal disease patients. Background. Transcobalamin II is a serum protein that transports vitamin B12 from the intestine to the tissues. This complex, holo-transcobalamin II, may reflect vitamin B12 availability in the body....

  • Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS. Katzmann, J A; Clark, R; Kyle, R A; Larson, D R; Therneau, T M; Melton, L J; Benson, J T; Colby, C L; Dispenzieri, A; Landgren, O; Kumar, S; Bradwell, A R; Cerhan, J R; Rajkumar, S V // Leukemia (08876924);Jan2013, Vol. 27 Issue 1, p208 

    We hypothesized that the suppression of uninvolved immunoglobulin in monoclonal gammopathy of undetermined significance (MGUS) as detected by suppression of the isotype-specific heavy and light chain (HLC-pair suppression) increases the risk of progression to malignancy. This approach required...

  • Male Accessory Gland Infection: Relevance of Serum Total Testosterone Levels. Condorelli, R. A.; Calogero, A. E.; Vicari, E.; Favilla, V.; Cimino, S.; Russo, G. I.; Morgia, G.; La Vignera, S. // International Journal of Endocrinology;2014, p1 

    Aim of the present study was to evaluate the different ultrasound characterization of fertile symptomatic patients withMAGI (male accessory gland infection) according to different serum concentrations of total T (TT).We analyzed the ultrasound and hormonal data of 200 patients aged between 24.0...

  • Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort. Nocturne, Gaetane; Pavy, Stephan; Boudaoud, Saida; Seror, Raphaèle; Goupille, Philippe; Chanson, Philippe; van der Heijde, Désirée; van Gaalen, Floris; Berenbaum, Francis; Mariette, Xavier; Briot, Karine; Feydy, Antoine; Claudepierre, Pascal; Dieudé, Philippe; Nithitham, Joanne; Taylor, Kimberly E.; Criswell, Lindsey A.; Dougados, Maxime; Roux, Christian; Miceli-Richard, Corinne // PLoS ONE;8/27/2015, Vol. 10 Issue 8, p1 

    Objectives: To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors. Methods: The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and...

  • Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis. Chang, Chun; Guo, Zhi-guo; He, Bei; Yao, Wan-zhen // Acta Pharmacologica Sinica;Nov2015, Vol. 36 Issue 11, p1356 

    Aim:To character the specific metabolomics profiles in the sera of Chinese patients with mild persistent asthma and to explore potential metabolic biomarkers.Methods:Seventeen Chinese patients with mild persistent asthma and age- and sex-matched healthy controls were enrolled. Serum samples were...

  • Effects of acupuncture on serum metabolic parameters in premenopausal obese women: study protocol for a randomized controlled trial. Koh-Woon Kim; Hye Hyun Yoo; Jae-Heung Cho; Yo-Chan Yang; Je-In Kim; Song-Yi Kim; Ji-Yeun Park; Hi-Joon Park; Mi-Yeon Song // Trials;Aug2015, Vol. 16 Issue 1, p1 

    Background: Complex metabolic changes cause obesity, making weight loss difficult. For this reason, understanding metabolism is important, and considering the shortcomings of conventional treatment options for obesity, acupuncture is a possible option. However, evidence supporting its efficacy...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics