TITLE

Phase II study of capecitabine and irinotecan combination chemotherapy in patients with advanced gastric cancer

AUTHOR(S)
Baek, J. H.; Kim, J. G.; Jeon, S. B.; Chae, Y. S.; Kim, D. H.; Sohn, S. K.; Lee, K. B.; Choi, Y. J.; Shin, H. J.; Chung, J. S.; Cho, G. J.; Jung, H. Y.; Yu, W.
PUB. DATE
May 2006
SOURCE
British Journal of Cancer;5/22/2006, Vol. 94 Issue 10, p1407
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
The present study was conducted to evaluate the efficacy and safety of a combination regimen of capecitabine plus irinotecan in patients with advanced gastric cancer. Patients with previously untreated metastatic or recurrent, measurable gastric cancer received oral capecitabine 1000 mg m(-2) twice daily from day 1 to 14 and intravenous irinotecan 100 mg m(-2) on days 1 and 8, based on a 3-week cycle. Forty-one patients were enrolled in the current study, among whom 38 were assessable for efficacy and 40 assessable for toxicity. Three complete responses and 16 partial responses were confirmed, giving an overall response rate of 46.3%. At a median follow-up of 269 days, the median time to progression and overall survival were 5.1 and 8.6 months, respectively. Grade 3/4 neutropenia occurred in four patients and grade 3 febrile neutropenia was observed in two patients. Grade 3 diarrhoea and grade 2 hand-foot syndrome occurred in six patients and eight patients, respectively. The combination of capecitabine and irinotecan was found to be well tolerated and effective in patients with advanced gastric cancer. Accordingly, this regimen can be regarded as one of first-line treatment options for advanced gastric cancer.
ACCESSION #
20927911

 

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