TITLE

Analysis of repeated pregnancy outcomes

AUTHOR(S)
Louis, Germaine Buck; Dukic, Vanja; Heagerty, Patrick J.; Louis, Thomas A.; Lynch, Courtney D.; Ryan, Louise M.; Schisterman, Enrique F.; Trumble, Ann; Lynch, Coutney D; Pregnancy Modeling Working Group
PUB. DATE
April 2006
SOURCE
Statistical Methods in Medical Research;Apr2006, Vol. 15 Issue 2, p103
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Women tend to repeat reproductive outcomes, with past history of an adverse outcome being associated with an approximate two-fold increase in subsequent risk. These observations support the need for statistical designs and analyses that address this clustering. Failure to do so may mask effects, result in inaccurate variance estimators, produce biased or inefficient estimates of exposure effects. We review and evaluate basic analytic approaches for analysing reproductive outcomes, including ignoring reproductive history, treating it as a covariate or avoiding the clustering problem by analysing only one pregnancy per woman, and contrast these to more modern approaches such as generalized estimating equations with robust standard errors and mixed models with various correlation structures. We illustrate the issues by analysing a sample from the Collaborative Perinatal Project dataset, demonstrating how the statistical model impacts summary statistics and inferences when assessing etiologic determinants of birth weight.
ACCESSION #
20197552

 

Related Articles

  • Comparison of subject-specific and population averaged models for count data from cluster-unit intervention trials. Young, Mary L.; Preisser, John S.; Qaqish, Bahjat F.; Wolfson, Mark // Statistical Methods in Medical Research;Apr2007, Vol. 16 Issue 2, p167 

    Maximum likelihood estimation techniques for subject-specific (SS) generalized linear mixed models and generalized estimating equations for marginal or population-averaged (PA) models are often used for the analysis of cluster-unit intervention trials. Although both classes of procedures account...

  • Induction of labor in twin pregnancy after 36 weeks does not increase maternal–fetal morbidity Harle, T.; Brun, J.L.; Leng, J.J. // International Journal of Gynecology & Obstetrics;Apr2002, Vol. 77 Issue 1, p15 

    Objective: To compare maternal and perinatal outcomes in twin pregnancy patients without any fetal or maternal disease, managed by labor induction or expectant management after 36 weeks gestation. Methods: We conducted a case–control study of 81 patients: labor induction (n=36) vs....

  • Adequacy of oophorectomy at the time of gynecologic surgery Muller, C.Y.; Coleman, R.L.; Toler, K.; Gibbons, D.; Ashfaq, R.; Voet, R.L. // International Journal of Gynecology & Obstetrics;Apr2002, Vol. 77 Issue 1, p23 

    Objectives: To determine the incidence of incomplete ovarian removal during gynecologic surgery and correlate the risk of inadequate removal with the procedure chosen. Methods: This is a prospective observational study. Ovaries received during a 4-month period in the participating institutions...

  • Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies. Pastorino, S; Bishop, T; Brage, S; Scherer, P; Wijndaele, K; Wareham, NJ; Ong, KK; Agyemang, C; Vrijkotte, TG; Zafarmand, MH; Wilson, RC; Burton, PR; O'Gorman, D; Dabelea, D; Kennedy, A; Desoye, G; Crozier, S R; Inskip, H M; Crozier, SR; Cooper, C // BJOG: An International Journal of Obstetrics & Gynaecology;Mar2019, Vol. 126 Issue 4, p459 

    Objective: Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes.Design: Individual level...

  • The International Collaboration on Air Pollution and Pregnancy Outcomes: Initial Results. Parker, Jennifer D.; Rich, David Q.; Glinianaia, Svetlana V.; Leem, Jong Han; Wartenberg, Daniel; Bell, Michelle L.; Bonzini, Matteo; Brauer, Michael; Darrow, Lyndsey; Gehring, Ulrike; Gouveia, Nelson; Grillo, Paolo; Ha, Eunhee; Hooven, Edith H. van den; Jalaludin, Bin; Jesdale, Bill M.; Lepeule, Johanna; Morello-Frosch, Rachel; Morgan, Geoffrey G.; Slama, Rémy // Environmental Health Perspectives;Jul2011, Vol. 119 Issue 7, p1023 

    BACKGROUND: The findings of prior studies of air pollution effects on adverse birth outcomes are difficult to synthesize because of differences in study design. OBJECTIVES: The International Collaboration on Air Pollution and Pregnancy Outcomes was formed to understand how differences in...

  • Five-year follow up of a low glycaemic index dietary randomised controlled trial in pregnancy-no long-term maternal effects of a dietary intervention. O'Brien, EC; Geraghty, AA; Horan, MK; Larkin, E; Donnelly, J; McAuliffe, FM; O'Sullivan, EJ; Riordan, JA; Twomey, PJ; Mehegan, J; O'Brien, E C; Geraghty, A A; Horan, M K; McAuliffe, F M; O'Sullivan, E J; Riordan, J A; Twomey, P J // BJOG: An International Journal of Obstetrics & Gynaecology;Mar2019, Vol. 126 Issue 4, p514 

    Objective: To determine whether a dietary intervention in pregnancy had a lasting effect on maternal outcomes of diet, HbA1c and weight retention 5 years post-intervention; and to establish whether modifiable maternal behaviours were associated with these outcomes.Design:...

  • External validation and clinical usefulness of first-trimester prediction models for small- and large-for-gestational-age infants: a prospective cohort study. Meertens, LJE; Smits, LJM; Kuijk, SMJ; Aardenburg, R; Langenveld, J; Dooren, IMA; Zwaan, IM; Spaanderman, MEA; Scheepers, HCJ; van Kuijk, Smj; van Dooren, Ima; Zwaan, I M // BJOG: An International Journal of Obstetrics & Gynaecology;Mar2019, Vol. 126 Issue 4, p472 

    Objective: To assess the external validity of all published first-trimester prediction models based on routinely collected maternal predictors for the risk of small- and large-for-gestational-age (SGA and LGA) infants. Furthermore, the clinical potential of the best-performing...

  • Wei, Lin and Weissfeld's marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome? Metcalfe, Chris; Thompson, Simon G. // Statistical Methods in Medical Research;Apr2007, Vol. 16 Issue 2, p103 

    Wei, Lin and Weissfeld (WLW) have applied an elaboration of Cox's proportional hazards regression to the analysis of recurrent events data. This application is controversial and has attracted criticism in a piecemeal fashion over 15 years. A frequently raised concern is the method's 'risk set':...

  • Prenatal and neonatal risk factors for schizophrenia. Hultman, Christina M.; Ohman, Arne; Cnattingius, Sven; Wieselgren, Ing-Marie; Lindström, Leif H.; Hultman, C M; Ohman, A; Cnattingius, S; Wieselgren, I M; Lindström, L H // British Journal of Psychiatry;Feb97, Vol. 170, p128 

    Background: The present study examines the effects of independent, single pre- and perinatal risk factors and rates of obstetric complications upon the subsequent development of schizophrenia.Method: This study was based on prospectively recorded birth records of 107...

  • Use of prenatal corticosteroids for preterm birth in three Latin American countries Riganti, Alicia Aleman; Cafferata, Maria Luisa; Althabe, Fernando; Gibbons, Luz; Segarra, Jose Ortiz; Sandoval, Xochitl; Belizán, José M.; Belizán, José M // International Journal of Gynecology & Obstetrics;Jan2010, Vol. 108 Issue 1, p52 

    Objective: To determine the prevalence of the use of prenatal corticosteroids in women who delivered prematurely in 3 Latin American counties and to evaluate the maternal characteristics associated with use.Methods: A multicenter, prospective, descriptive study was...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics