TITLE

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study

AUTHOR(S)
Sprung, Charles L.; Sakr, Yasser; Vincent, Jean-Louis; Le Gall, Jean-Roger; Reinhart, Konrad; Ranieri, V. Marco; Gerlach, Herwig; Fielden, Jonathan; Groba, C. B.; Payen, Didier
PUB. DATE
March 2006
SOURCE
Intensive Care Medicine;Mar2006, Vol. 32 Issue 3, p421
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.Design and Setting: Cohort, multicentre, observational study of 198 ICUs in 24 European countries.Patients and Interventions: All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.Results: During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.Conclusions: Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.
ACCESSION #
19835721

 

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