An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study

Sprung, Charles L.; Sakr, Yasser; Vincent, Jean-Louis; Le Gall, Jean-Roger; Reinhart, Konrad; Ranieri, V. Marco; Gerlach, Herwig; Fielden, Jonathan; Groba, C. B.; Payen, Didier
March 2006
Intensive Care Medicine;Mar2006, Vol. 32 Issue 3, p421
Academic Journal
journal article
Objective: To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.Design and Setting: Cohort, multicentre, observational study of 198 ICUs in 24 European countries.Patients and Interventions: All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.Results: During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.Conclusions: Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.


Related Articles

  • Other supportive therapies in sepsis. Pérez, Javier; Dellinger, R. Phillip // Intensive Care Medicine;Feb2001 Supplement 1, Vol. 27, pS116 

    Discusses supportive therapies for patients with sepsis. Importance of nutritional support in supporting the critically ill septic patient who is unable to eat; Impact of sepsis and the associated organ dysfunction on the patient's risk for development of stress ulcers.

  • Pharmacokinetic evaluation of meropenem and imipenem in critically ill patients with sepsis. Novelli, Andrea; Adembri, Chiara; Livi, Paola; Fallani, Stefania; Mazzei, Teresita; De Gaudio, Angelo Raffaele // Clinical Pharmacokinetics;2005, Vol. 44 Issue 5, p539 

    Objective: To evaluate and compare the pharmacokinetic profiles of imipenem and meropenem in a population of critically ill patients with sepsis to find possible differences that may help in selecting the most appropriate drug and/or dosage in order to optimise empiric antimicrobial...

  • Daily organ-system failure for diagnosis of persistent intra-abdominal sepsis after postoperative peritonitis. Paugam-Burtz, C.; Dupont, H.; Marmuse, J.-P.; Chosidow, D.; Malek, L.; Desmonts, J.-M.; Mantz, J. // Intensive Care Medicine;May2002, Vol. 28 Issue 5, p594 

    Objective: To evaluate the time-course of two organ failure scores (SOFA and Goris) after surgery for postoperative peritonitis in critically ill patients according to the persistence/nonpersistence of intraabdominal sepsis (IAS). Design: Retrospective study. Patients: Sixty-two consecutive...

  • Occult splenic rupture with cardiovascular collapse: a report of three cases in critically ill patients. Subramani, Kandasamy; Thomas, Antony N.; Reeve, Roy S. // Intensive Care Medicine;Dec2002, Vol. 28 Issue 12, p1819 

    Three cases of splenic rupture causing cardiovascular collapse in critically ill patients are discussed. The first patient had received cardiopulmonary resuscitation (CPR) in the days before the collapse, the second patient was recovering from severe sepsis and the third patient was recovering...

  • Dear Sirs, what is your PCT? Vincent, J.-L.; Mercan, D. // Intensive Care Medicine;Sep2000, Vol. 26 Issue 9, p1170 

    Comments on the value of procalcitonin in the diagnosis of sepsis in acutely ill patients. Difficulty in diagnosing sepsis in critically ill; Potential of procalcitonin as markers of sepsis; Pathways of the infectious process.

  • Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study. Jason A. Roberts; Rob Boots; Claire M. Rickard; Peter Thomas; Jo Quinn; Darren M. Roberts; Brent Richards; Jeffrey Lipman // Journal of Antimicrobial Chemotherapy (JAC);Feb2007, Vol. 59 Issue 2, p285 

    Objectives: To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion. Patients and methods: We conducted an open-label, randomized...

  • Management of the critically ill child with sepsis. Playfor, Stephen // Continuing Education in Anaesthesia, Critical Care & Pain;Feb2004, Vol. 4 Issue 1, p12 

    Sepsis is broadly understood to be the systemic response to infection. It can be said to exist when an infectious process has triggered the systemic inflammatory response syndrome (SIRS). The term ‘SIRS’ was coined in 1992 by the American College of Chest Physicians and Society of...

  • Increased endogenous carbon monoxide production in severe sepsis. Zegdi, Rachid; Perrin, Dominique; Burdin, Michèle; Boiteau, Richard; Tenaillon, Alain // Intensive Care Medicine;Jun2002, Vol. 28 Issue 6, p793 

    Objective: A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis. Design: Prospective comparative study. Setting: Medical ICU in a community hospital. Patients: Twenty-four...

  • Hyperbaric oxygen and sepsis: time to recognize. Muth, Claus-Martin; Radermacher, Peter; Cuzzocrea, Salvatore // Intensive Care Medicine;Sep2005, Vol. 31 Issue 9, p1150 

    Studies the application of hyperbaric oxygen therapy (HBO) in the treatment of sepsis. Indications that HBO therapy alone or as an adjunct has beneficial effects for sepsis patients; Beneficial effects of HBO exposure in experimental models of systemic inflammation; Implications for critical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics