TITLE

Post-treatment dopexamine infusions partially reverse reductions in cranial mesenteric blood flow and mucosal oxygenation induced by hypoxia in newborn piglets

AUTHOR(S)
Aliabadi-Wahle, S.; Choe, E.U.; Flint, L.M.; Ferrara, John J.; Ferrara, J J
PUB. DATE
June 1999
SOURCE
American Surgeon;Jun1999, Vol. 65 Issue 6, p548
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
A severe hypoxic insult is known to induce dramatic reductions in newborn intestinal blood flow and is, thus, considered a vector for the development of neonatal intestinal ischemic diseases. Dopexamine (DPX) is a novel synthetic agent that has potent B2-adrenoceptor and dopaminergic activity, the clinical effects of which include an increase in cardiac output and in mesenteric blood flow. Having previously shown that infusion of DPX before hypoxia (HYP) mitigated the reduction in newborn mesenteric blood flow, we sought to define its efficacy when given after an established hypoxic insult. Ultrasonic transit time blood flow probes were placed around the ascending aorta and cranial mesenteric artery of anesthetized, mechanically ventilated 0 to 2-day-old piglets. Small bowel mucosal oxygenation was observed with a tissue oxygen monitoring system. After stabilization, animals were subjected to one of the following: HYP (FIO2 = 0.12) for 60 minutes (n = 12); DPX (5 microg/kg/min) infusion begun 10 minutes after induction of HYP/DPX (n = 11). Almost no alterations in any of the monitored variables were shown in a group (n = 5) of similarly instrumented, untreated animals. In contrast, although both hypoxic piglet groups experienced significant (P < 0.05, analysis of variance) declines from baseline cardiac output, mesenteric blood flow, and mucosal oxygenation, each of these deleterious effects was significantly (P < 0.05) blunted in the DPX-treated animals. During periods of systemic hypoxemia, the reductions in neonatal mesenteric blood flow and oxygenation can be somewhat blunted by DPX. As such, this agent may prove of clinical benefit when an infant is threatened by a hypoxic episode.
ACCESSION #
1932115

 

Related Articles

  • Synthetic drug-test tissue eliminates need for animals.  // Engineer (Online Edition);7/6/2011, p7 

    The article examines the synthetic tissue developed by Reading University researchers, that can be used to assess quality of drugs under laboratory development. It is stated that medicine tablets can attach to mucosal tissue like the mouth and stomach to extend time the drugs remain in the body....

  • DES hazards: Not for women only. D'Epiro, Nancy Walsh // Patient Care;9/30/1997, Vol. 31 Issue 15, p7 

    Focuses on the risk factors which girls whose mothers took the synthetic estrogen diethylstilbestrol (DES) encounters in the prevention of miscarriages. Reference to the issuing of a book by the National Cancer Institute of Child Health and Human Development; Affects associated with the...

  • How safe are herbs? Sierra, Andrew; Rubin, Aaron // Physician & Sportsmedicine;Jul98, Vol. 26 Issue 7, p65 

    Reports that a review of literature on a selection of botanical medications, summarized the side effects of herbs and compared their safety with that of synthetic drugs. Identity of various herbs; Allergic reactions that can be triggered by herbal drugs; Why there is a call for systematic...

  • UN CAZ DE TRATAMENT CU AMBRA GRISEA. Iacob, ConstanĊ£a // Romanian Medical Journal;2011, Vol. 58 Issue 3, p211 

    In today's world of the use and abuse of synthetic drugs, given the alarming increase in the number of serious diseases, it is necessary a reformulation of how to look and understand the medical reality. Currently, allopathic doctors have expanded the horizon of medical knowledge including the...

  • Societal Trends in Drug Use and Policy.  // Journal of Global Drug Policy & Practice;Summer2016, Vol. 10 Issue 2, p1 

    An introduction is presented in which the editor discusses various reports within the issue on topics including the impact of using marijuana at a hospital emergency department in Colorado Springs, Colorado, synthetic drugs, and pain treatment using opioids.

  • ANABOLIC STEROIDS. Laron, Zvi; Gitter, Simon // Clinical Pediatrics;Nov1963, Vol. 2 Issue 11, p594 

    Discusses the pharmacological properties of anabolic steroids and their clinical use and specific dangers in pediatrics. Increase nitrogen retention and protein synthesis during administration; Changes in the weight of levator ani muscle and seminal vesicles; Alteration in the sexual organs of...

  • Effect of 4-aminopyridine and single-dose methylprednisolone on functional recovery after a chronic spinal cord injury. Haghighi, Siavash S; Clapper, Adam; Johnson, Gayle C; Stevens, Amy; Prapaisilp, Arisa // Spinal Cord;Jan1998, Vol. 36 Issue 1, p6 

    The demyelination process is an important factor contributing to long term sensory and motor impairments after spinal cord injury (SCI). Exposure of axonal K+ channels after demyelination may contribute to blockage of action potentials across the injury site. A K+ channel blocker,...

  • Establishing Bioequivalence in Serial Sacrifice Designs. Martin Wolfsegger // Journal of Pharmacokinetics & Pharmacodynamics;Feb2007, Vol. 34 Issue 1, p103 

    Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in human subjects. The classic complete data design, where each animal is sampled for analysis once per time point, is usually only applicable for large animals...

  • Reduction of MPO-ANCA epitopes in SCG/Kj mice by 15-deoxyspergualin treatment restricted by IgG2b associated with crescentic glomerulonephritis. Tomizawa, Kazuo; Nagao, Tomokazu; Kusunoki, Reina; Saiga, Kan; Oshima, Masamichi; Kobayashi, Kazuo; Nakayama, Toshinori; Tanokura, Masaru; Suzuki, Kazuo // Rheumatology;Jul2010, Vol. 49 Issue 7, p1245 

    Objectives. The MPO-specific antineutrophil cytoplasmic antibodies (MPO-ANCA) are associated with renal failure. Epitopes of MPO-ANCA and immunoglobulin G (IgG) subclass and cytokine levels in the recovery phase were analysed by the administration of 15-deoxyspergualin (DSG) to SCG/Kj mice,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics