TITLE

Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus

AUTHOR(S)
Wagner, Verena M.; Müller-Godeffroy, Esther; Von Sengbusch, Simone; Häger, Stefan; Thyen, Ute; Müller-Godeffroy, Esther; Häger, Stefan
PUB. DATE
August 2005
SOURCE
European Journal of Pediatrics;Aug2005, Vol. 164 Issue 8, p491
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Unlabelled: The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being (P < 0.05) and children higher levels of well-being in the school domain (P < 0.05). In general, children reported a better HRQOL (P < 0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains (P < 0.05). The subscale "chronic illness" showed a better HRQOL (P < 0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions.Conclusion: Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.
ACCESSION #
17719939

 

Related Articles

  • Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control. Famulla, Susanne; Hövelmann, Ulrike; Fischer, Annelie; Coester, Hans-Veit; Hermanski, Lidia; Kaltheuner, Matthias; Kaltheuner, Lars; Heinemann, Lutz; Heise, Tim; Hirsch, Laurence // Diabetes Care;Sep2016, Vol. 39 Issue 9, p1486 

    Objective: Lipohypertrophy (LHT) is common in insulin-treated patients but its exact impact on insulin absorption and action is unclear.Research Design and Methods: In this crossover study, 13 patients with type 1 diabetes received subcutaneous abdominal injections of...

  • Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach. Schwandt, Anke; Hermann, Julia M.; Rosenbauer, Joachim; Boettcher, Claudia; Dunstheimer, Désirée; Grulich-Henn, Jürgen; Kuss, Oliver; Rami-Merhar, Birgit; Vogel, Christian; Holl, Reinhard W.; DPV Initiative // Diabetes Care;Mar2017, Vol. 40 Issue 3, p309 

    Objective: Worsening of glycemic control in type 1 diabetes during puberty is a common observation. However, HbA1c remains stable or even improves for some youths. The aim is to identify distinct patterns of glycemic control in type 1 diabetes from childhood to young...

  • Predictive Hyperglycemia and Hypoglycemia Minimization: In-Home Evaluation of Safety, Feasibility, and Efficacy in Overnight Glucose Control in Type 1 Diabetes. Spaic, Tamara; Driscoll, Marsha; Raghinaru, Dan; Buckingham, Bruce A.; Wilson, Darrell M.; Clinton, Paula; Chase, H. Peter; Maahs, David M.; Forlenza, Gregory P.; Jost, Emily; Hramiak, Irene; Paul, Terri; Bequette, B. Wayne; Cameron, Faye; Beck, Roy W.; Kollman, Craig; Lum, John W.; Ly, Trang T.; In-Home Closed-Loop (IHCL) Study Group // Diabetes Care;Mar2017, Vol. 40 Issue 3, p359 

    Objective: The objective of this study was to determine the safety, feasibility, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system compared with predictive low-glucose insulin suspension (PLGS) alone in overnight glucose control.Research...

  • Insulin is required for prandial ghrelin suppression in humans. Murdolo, Giuseppe; Lucidi, Paola; Di Loreto, Chiara; Parlanti, Natascia; De Cicco, Arianna; Fatone, Cristina; Fanelli, Carmine G.; Bolli, Geremia B.; Santeusanio, Fausto; De Feo, Pierpaolo // Diabetes;Dec2003, Vol. 52 Issue 12, p2923 

    Accumulating evidence indicates that ghrelin plays a role in regulating food intake and energy homeostasis. In normal subjects, circulating ghrelin concentrations decrease after meal ingestion and increase progressively before meals. At present, it is not clear whether nutrients suppress the...

  • HbA1c and the Prediction of Type 2 Diabetes in Children and Adults. Vijayakumar, Pavithra; Nelson, Robert G.; Hanson, Robert L.; Knowler, William C.; Sinha, Madhumita // Diabetes Care;Jan2017, Vol. 40 Issue 1, p16 

    Objective: Long-term data validating glycated hemoglobin (HbA1c) in assessing the risk of type 2 diabetes in children are limited. HbA1c, fasting plasma glucose (FPG), and 2-h postload plasma glucose (2hPG) concentrations were measured in a longitudinal study of American Indians to...

  • Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype. Al-Majdoub, Mahmoud; Ali, Arslan; Storm, Petter; Rosengren, Anders H.; Groop, Leif; Spégel, Peter // Diabetes;Apr2017, Vol. 66 Issue 4, p806 

    Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA from type 1 or type 2 diabetes. In...

  • Adrenaline and cortisol levels are lower during nighttime than daytime hypoglycaemia in children with type 1 diabetes. Fredheim, S.; Foli‐Andersen, P.; Lærkholm, G.; Svensson, J.; Juhl, C. B.; Olsen, B.; Pilgaard, K.; Johannesen, J.; Foli-Andersen, P; Laerkholm, G // Acta Paediatrica;Oct2018, Vol. 107 Issue 10, p1759 

    Aim: We investigated children's counter regulatory hormone profiles during a hyperinsulinaemic hypoglycaemic clamp procedure at day and night.Methods: In 2013, we assessed the counter regulatory response to hypoglycaemia in eight outpatients with type 1 diabetes,...

  • Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial. Kropff, Jort; Choudhary, Pratik; Neupane, Sankalpa; Barnard, Katharine; Bain, Steve C.; Kapitza, Christoph; Forst, Thomas; Link, Manuela; Dehennis, Andrew; DeVries, J. Hans // Diabetes Care;Jan2017, Vol. 40 Issue 1, p63 

    Objective: It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits.Research Design and Methods: We studied the Eversense...

  • A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes. Rooijackers, Hanne M.; Wiegers, Evita C.; van der Graaf, Marinette; Thijssen, Dick H.; Kessels, Roy P. C.; Tack, Cees J.; de Galan, Bastiaan E. // Diabetes;Jul2017, Vol. 66 Issue 7, p1990 

    High-intensity interval training (HIIT) has gained increasing popularity in patients with diabetes. HIIT acutely increases plasma lactate levels. This may be important, since the administration of lactate during hypoglycemia suppresses symptoms and counterregulation while preserving cognitive...

  • Six months of hybrid closed loop in the real‐world: An evaluation of children and young adults using the 670G system. Berget, Cari; Messer, Laurel H.; Vigers, Tim; Frohnert, Brigitte I.; Pyle, Laura; Wadwa, R. Paul; Driscoll, Kimberly A.; Forlenza, Gregory P. // Pediatric Diabetes;Mar2020, Vol. 21 Issue 2, p310 

    Objective: To describe glycemic and psychosocial outcomes in youth with type 1 diabetes using a hybrid closed loop (HCL) system. Subjects: Youth with type 1 diabetes (2‐25 years) starting the 670G HCL system for their diabetes care were enrolled in an observational study. Methods:...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics