TITLE

On group sequential procedures under variance heterogeneity

AUTHOR(S)
Hussein, A.; Carriere, K. C.
PUB. DATE
April 2005
SOURCE
Statistical Methods in Medical Research;Apr2005, Vol. 14 Issue 2, p121
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
In this paper, we consider group sequential procedures for clinical trials under variance heterogeneity. Group sequential procedures typically involve small samples at each interim analysis. We advocate Welch's correction for variance heterogeneity, and present a natural application of the significance level method for such situations. Currently available procedures are based on a large sample method, with no allowance for corrections of heterogeneity. Unless the sample size is large, the results are not valid. On the basis of simulation studies, comparing their abilities to control Type I error rates, we recommend using Welch's correction for sequential trials involving small samples under variance heterogeneity.
ACCESSION #
16810748

 

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