Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease

Dittrich, S.; Germanakis, J.; Dähnert, I.; Stiller, B.; Dittrich, H.; Vogel, M.; Lange, P. E.; Dähnert, I
July 2003
Intensive Care Medicine;Jul2003, Vol. 29 Issue 7, p1141
Academic Journal
journal article
Objectives: To check the hypothesis that continuous magnesium infusion protects the heart from arrhythmias following cardiopulmonary bypass surgery for congenital heart disease.Design: A prospective randomised placebo-controlled study, with patients stratified in three weight groups.Patients and Participants: The study group ( n=65) postoperatively received a magnesium infusion (1 mmol/kg), the control group ( n=66) received placebo. In both groups serum and ionised magnesium values were followed, and all postoperative arrhythmias were documented for 24 h.Measurements and Results: Serum and ionised magnesium in the blood was elevated after the end of bypass (0.54+/-0.15 mmol l(-1) pre-operatively, 0.88+/-0.24 mmol l(-1) postoperatively), where a cardioplegia solution containing magnesium was used. Magnesium values remained at this elevated level in the magnesium therapy group, and decreased to normal pre-operative values within 24 h in controls ( P<0.001). The incidence of postoperative arrhythmias was lower in the study group: 8/65 in the study group and 17/66 in the control group, respectively (chi-squared test, P=0.05). Lower patient weight (32.7 kg versus 22.6 kg), longer cardiopulmonary bypass time (128.7 min versus 87.9 min) and deeper body temperature during extracorporeal circulation (29.2 degrees C versus 32.6 degrees C) were identified as risk factors for postoperative arrhythmias ( P<0.05).Conclusions: Continuous magnesium infusion effectively reduces the rate of arrhythmias following cardiopulmonary bypass surgery for congenital heart disease and should, therefore, be routinely used.


Related Articles

  • Mid-term Outcomes of Common Congenital Heart Defects Corrected Through a Right Subaxillary Thoracotomy. An, Guoying; Zhang, Hongyu; Zheng, Shanguang; Wang, Weixin; Ma, Liming // Heart, Lung & Circulation;Apr2017, Vol. 26 Issue 4, p376 

    Objective: To evaluate the mid-term outcomes of the correction of various congenital heart defects through a right subaxillary thoracotomy.Methods: Between June 2004 and April 2014, all eligible patients were those with a common congenital heart defect corrected via an...

  • A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users. Ashton, C.H.; Rawlings, M.D.; Tyrer, S.P.; Rawlins, M D // British Journal of Psychiatry;Aug90, Vol. 157, p232 

    A double-blind placebo-controlled trial of 23 chronic benzodiazepine users showed that overall, buspirone did not appear to be helpful in alleviating benzodiazepine withdrawal symptoms. Buspirone (5 mg t.d.s.) or placebo was administered for four weeks before, during and after diazepam...

  • Cervical priming with sublingual misoprostol vs. 15-methyl-prostaglandin F2α prior to surgical abortion Vimala, N.; Mittal, S.; Dadhwal, V. // International Journal of Gynecology & Obstetrics;Feb2005, Vol. 88 Issue 2, p134 

    Abstract: Objective: To compare the efficacy and tolerability of sublingual misoprostol with those of intramuscular 15-methyl-prostaglandin F2α (15-M-PG F2α) for cervical dilation prior to vacuum aspiration (VA) in first-trimester pregnancy termination. Methods: Sixty pregnant women...

  • Fresh Whole Blood versus Reconstituted Blood for Pump Priming in Heart Surgery in Infants. Mou, Steven S.; Giroir, Brett P.; Molitor-Kirsch, Erica A.; Leonard, Steven R.; Nikaidoh, Hisashi; Nizzi, Frank; Town, Deborah A.; Roy, Lonnie C.; Scott, William; Stromberg, Daniel // New England Journal of Medicine;10/14/2004, Vol. 351 Issue 16, p1635 

    Background: In an attempt to reduce the coagulopathic and inflammatory responses seen after cardiopulmonary bypass, the use of fresh whole blood during heart operations has become the standard of care for neonates and infants at many institutions. We compared the use of fresh whole blood with...

  • Absorbable subcuticular staples versus suture for caesarean section closure: a randomised clinical trial. Madsen, AM; Dow, ML; Tessmer‐Tuck, JA; Lohse, CM; Madsen, A M; Dow, M L; Tessmer-Tuck, J A; Lohse, C M // BJOG: An International Journal of Obstetrics & Gynaecology;Mar2019, Vol. 126 Issue 4, p502 

    Objective: To compare outcomes of efficiency, safety, patient, and surgeon satisfaction between absorbable subcuticular staples and subcuticular suture for caesarean section skin closure.Design: A prospective, randomised, non-blinded, parallel-group trial.Setting:...

  • Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study. Valipour, Arschang; Slebos, Dirk-Jan; Herth, Felix; Darwiche, Kaid; Wagner, Manfred; Ficker, Joachim H.; Petermann, Christoph; Hubner, Ralf-Harto; Stanzel, Franz; Eberhardt, Ralf; IMPACT Study Team // American Journal of Respiratory & Critical Care Medicine;11/1/2016, Vol. 194 Issue 9, p1073 

    Rationale: Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema.Objectives: To evaluate the efficacy and...

  • Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study. Sargın, Mehmet; Uluer, Mehmet Selçuk; Aydoğan, Eyüp // Medical Principles & Practice;Apr2018, Vol. 27 Issue 1, p1 

    Objective: In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection.Subjects and Methods: In this prospective, randomized, placebo-controlled and double-blind trial, 60 patients scheduled to...

  • Passive movement and active exercise for very young infants with congenital heart disease: a study protocol for a randomized controlled trial. Qing Du; Xuan Zhou; Xueqiang Wang; Sun Chen; Xiaoyan Yang; Nan Chen; Juping Liang; Weiwei Deng; Kun Sun; Du, Qing; Zhou, Xuan; Wang, Xueqiang; Chen, Sun; Yang, Xiaoyan; Chen, Nan; Liang, Juping; Deng, Weiwei; Sun, Kun // Trials;2015, Vol. 16 Issue 1, p1 

    Background: Delayed motor development is reported in patients with congenital heart disease (CHD). Exercise is widely used to facilitate motor development and improve motor ability. Exercise for adolescents and adults with CHD has been extensively studied. However, the evidence of...

  • Comparison of the Effectiveness of Continuous versus Intermittent Cefazolin for the Prevention of Infection after Off-Pump Coronary Artery Bypass Graft. Forouzannia, Seyed Khalil; Karimi-Bondarabadi, Ali Akbar; Bagherinasab, Mostafa; Sarebanhassanabadi, Mohammadtaghi // Journal of Tehran University Heart Center;2014, Vol. 9 Issue 3, p120 

    Background: Surgical site infection is known as a common complication after cardiac surgery, and Cefazolin is the best prophylactic antibiotic to prevent this complication. The goal of this study was to evaluate the effect of continuous and intermittent Cefazolin for the prevention of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics