TITLE

Fuzzy set analyses of genetic determinants of health and disability status

AUTHOR(S)
Manton, Kenneth G.; Xiliang Gu; Hai Huang; Kovtun, Mikhail; Gu, Xiliang; Huang, Hai
PUB. DATE
October 2004
SOURCE
Statistical Methods in Medical Research;Oct2004, Vol. 13 Issue 5, p395
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Analyses of complex genotype-phenotype relations require new statistical procedures because of the potentially high dimensionability of those relations which are expressed with both measurement error and stochasticity in the correlation function. We propose modifying a multivariate procedure called grade of membership (GoM) analysis to deal with the special problems of such analyses. In doing so, we make clear some special features of the GoM model for multivariate analysis of high dimensional, discrete data. This is illustrated for apolipoprotein E (APOE) assessments made on 1805 people in the 1999 National Long Term Care Survey. A number of interesting relations with APOE polymorphism were found where disability profiles were more predictive than specific diagnoses because they implicitly contained information on chronicity and severity of disease processes.
ACCESSION #
14509724

 

Related Articles

  • Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype. Leclercq, P. D.; Murray, I. S.; Smith, C.; Graham, D. I.; Nicoll, J. A. R.; Gentleman, S. M.; Murray, L S // Journal of Neurology, Neurosurgery & Psychiatry;Feb2005, Vol. 76 Issue 2, p229 

    Objective: In view of the association of the apolipoprotein E (APOE) epsilon 4 allele with poor outcome after traumatic brain injury we determined the frequency of cerebral amyloid angiopathy (CAA) and the extent of haemorrhagic pathology in relation to APOE genotype in an autopsy...

  • Longevity and correlated frailty in multigenerational families. Garibotti, Gilda; Smith, Ken R; Kerber, Richard A; Boucher, Kenneth M // Journals of Gerontology Series A: Biological Sciences & Medical ;Dec2006, Vol. 61 Issue 12, p1253 

    Multigenerational pedigrees provide an opportunity for assessing the effects of unobserved environmental and genetic effects on longevity (i.e., frailty). This article applies Cox proportional hazards models to data from three-generation pedigrees in the Utah Population Database using two...

  • Analysis of uncertainty in health care cost-effectiveness studies: an introduction to statistical issues and methods. O'Brien, B. J.; Briggs, A. H. // Statistical Methods in Medical Research;Dec2002, Vol. 11 Issue 6, p455 

    Cost-effectiveness analysis is now an integral part of health technology assessment and addresses the question of whether a new treatment or other health care program offers good value for money. In this paper we introduce the basic framework for decision making with cost-effectiveness data and...

  • Mitochondria. Chinnery P F; Schon E A; Chinnery, P F; Schon, E A // Journal of Neurology, Neurosurgery & Psychiatry;Sep2003, Vol. 74 Issue 9, p1188 

    Following the discovery in the early 1960s that mitochondria contain their own DNA (mtDNA), there were two major advances, both in the 1980s: the human mtDNA sequence was published in 1981, and in 1988 the first pathogenic mtDNA mutations were identified. The floodgates were opened, and the...

  • Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer. Mrkonjic, M.; Chappell, E.; Pethe, V. V.; Manno, M.; Daftary, D.; Greenwood, C. M.; Gallinger, S.; Zanke, B. W.; Knight, J. A.; Bapat, B. // British Journal of Cancer;6/16/2009, Vol. 100 Issue 12, p1966 

    ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in...

  • Apolipoprotein E and coronary disease: a puzzling paradox. Reilly, Muredach; Rader, Daniel J. // PLoS Medicine;Jun2006, Vol. 3 Issue 6, pe258 

    The article discusses the relationship between apolipoprotein E (apoE) and coronary disease. The effect of apoE on lipoprotein metabolism and the vasculature is considered. The anti-atherogenic properties of apoE are identified. Evidences on the clear association of apoE and atherosclerosis are...

  • Ability to walk 1/4 mile predicts subsequent disability, mortality, and health care costs. Hardy, Susan E.; Yihuang Kang; Studenski, Stephanie A.; Degenholtz, Howard B.; Kang, Yihuang // JGIM: Journal of General Internal Medicine;Feb2011, Vol. 26 Issue 2, p130 

    Background: Mobility, such as walking 1/4 mile, is a valuable but underutilized health indicator among older adults. For mobility to be successfully integrated into clinical practice and health policy, an easily assessed marker that predicts subsequent health outcomes is...

  • Invited Commentary: Repeated Measures, Selection Bias, and Effect Identification in Neighborhood Effect Studies. Oakes, J. Michael // American Journal of Epidemiology;Oct2014, Vol. 180 Issue 8, p785 

    Research on neighborhood effects faces enormous methodological challenges, with selection bias being near the top of the list. In this issue of the Journal (Am J Epidemiol. 2014;180(8):776–784), Professor Jokela addresses this issue with novel repeated measures data and models that...

  • Decision analytical economic modelling within a Bayesian framework: application to prophylactic antibiotics use for caesarean section. Cooper, N J; Sutton, A J; Abrams, K R // Statistical Methods in Medical Research;Dec2002, Vol. 11 Issue 6, p491 

    Economic evaluation of health care interventions based on decision analytic modelling can generate valuable information for health policy decision makers. However, the usefulness of the results obtained depends on the quality of the data input into the model; that is, the accuracy of the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics