Subareolar injection of radioactive colloid for sentinel lymph node identification in breast cancer patients

Péley, Gábor; Sinkovics, István; Tóth, József; Farkas, Emil; Keresztes, Sándor; Köves, István; Péley, Gábor; Sinkovics, István; Tóth, József; Keresztes, Sándor; Köves, István
July 2004
American Surgeon;Jul2004, Vol. 70 Issue 7, p625
Academic Journal
journal article
Sentinel lymph node biopsy (SLNB) is becoming the standard for staging the axilla in breast cancer patients in many institutions. The best method of injection is still questionable. The purpose of this study was to compare the results of SLNB using the peritumoral or the subareolar injection site. Between December 1997 and March 2000, we performed 100 SLNBs. Technecium-labeled colloidal human serum albumin was injected peritumorally (Group A, 31 patients; Group B, 31 patients) or subareolarly (Group C, 38 patients). Patent blue dye was given periareolarly (Group A) or peritumorally (Groups B and C). Preoperative lymphoscintigraphy was performed in all patients. SLNB was successful in 94 patients (94%). The identification rate improved from 80 per cent (first 25 patients) to 99 per cent (last 75). The subareolar injection of the colloid did not adversely influence the results of SLNB compared with the peritumoral injection (identification rate, 100% vs 97%; false negative rate, 6% vs 14%). The subareolar injection of colloid is a simple and at least as accurate technique as the peritumoral one. This technique can also improve the identification rate of SLNB for breast cancer patients.


Related Articles

  • Sentinel lymph node detection with large human serum albumin colloid particles in breast cancer. Mirzaei, S.; Rodrigues, M.; Hoffmann, B.; Knoll, P.; Riegler-Keil, M.; Kreuzer, W.; Salzer, H.; Köhn, H.; Polyák, A.; Jánoki, G. A. // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 6, p874 

    Detection of metastatic involvement of lymph nodes is essential for management and prognostic evaluation in breast cancer patients. The success of lymphatic mapping depends on identifying the sentinel lymph node(s) draining the primary tumour. However, when mapping is performed with a...

  • The Feasibility and Accuracy of the Sentinel Lymph Node Biopsy for Breast Carcinoma. Jaderborg, Jana M; Harrison, Paul B. // American Surgeon;Aug1999, Vol. 65 Issue 8, p699 

    As the procedure of sentinel lymph node biopsy for breast cancer becomes more widely available, the practicality of it in the hands of general surgeons should be assessed. This is a study of the accuracy and use of this procedure. A prospective study was conducted at two university-affiliated...

  • Practice patterns of lymph-node mapping and sentinel-node biopsy for breast cancer in British Columbia. Chua, Boon; Olivotto, Ivo A.; Donald, James C.; Hayashi, Allen H.; Davis, Noelle; Rusnak, Conrad H. // Canadian Journal of Surgery;Aug2003, Vol. 46 Issue 4, p273 

    Examines practice patterns for sentinel-node biopsy (SNB) for breast cancer in British Columbia. Techniques for the surgical, imaging and pathologic assessments of SNB; Training of surgeons; Immunohistochemical evaluation of the sentinel nodes.

  • Early Adoption and Disturbing Disparities in Sentinel Node Biopsy in Breast Cancer. Edge, Stephen B. // JNCI: Journal of the National Cancer Institute;4/2/2008, Vol. 100 Issue 7, p449 

    The article discusses a paper on the use of sentinel lymph node biopsy (SLNB) in breast cancer that is published within this issue.

  • Eighteen Sensations After Breast Cancer Surgery: A Comparison of Sentinel Lymph Node Biopsy and Axillary Lymph Node Dissection. Baron, Roberta H.; Fey, Jane V.; Raboy, Sara; Thaler, Howard T.; Borgen, Patrick I.; Temple, Larissa K.F.; Van Zee, Kimberly J. // Oncology Nursing Forum;May2002, Vol. 29 Issue 4, p651 

    Purpose/Objectives: To evaluate prevalence, severity, and level of distress of 18 sensations at 3u15 days (baseline), 3 months, and 6 months after breast cancer surgery; to compare sentinel lymph node biopsy (SLNB) to SLNB with immediate or delayed axillary lymph node dissection; to evaluate the...

  • Sentinel node biopsy: studies should bring needed data. McNeil, Caroline; McNeil, C // JNCI: Journal of the National Cancer Institute;05/20/98, Vol. 90 Issue 10, p728 

    Presents information on sentinel node biopsy, in relation to breast cancer. Comments from doctor, Armando Giuliano; Details on the surgical performance for the removal of nodes in the breast; Indepth look at a vote by the committee of the Philadelphia-based NCCN on the inclusion of sentinel...

  • Emergence of Sentinel Node Biopsy in Breast Cancer as Standard-of-Care in Academic Comprehensive Cancer Centers. Edge, Stephen B.; Niland, Joyce C.; Bookman, Michael A.; Theriault, Richard L.; Ottesen, Rebecca; Lepisto, Eva; Weeks, Jane C. // JNCI: Journal of the National Cancer Institute;10/15/2003, Vol. 95 Issue 20, p1514 

    Background: Ongoing clinical trials are addressing the accuracy and safety of sentinel node biopsy (SNB) in the treatment of breast cancer; however, SNB is already increasingly being used in clinical practice. This study examined the extent and time trends of the use of SNB in stage I and II...

  • SLNB or ALND for staging of EBC in Australia?  // PharmacoEconomics & Outcomes News;4/14/2012, Issue 651, p8 

    The article discusses research on the effectiveness and cost effectiveness of sentinel lymph node biopsy compared with axillary node dissection in patients with early-stage breast cancer, referencing a study by H. Verry and colleagues published on the March 13, 2012 issue of the "British Journal...

  • Blue Nodes Left Behind After Vital Blue Dye-guided Axillary Sentinel Node Biopsy in Breast Cancer Patients. Cserni, Gábor; Rajtár, Mária; Boross, Gábor // Japanese Journal of Clinical Oncology;Jun2000, Vol. 30 Issue 6, p263 

    Attempts to assess the frequency of blue nodes missed during vital dye-guided sentinel node biopsy. False nodal staging of breast carcinomas; Histological assessment of sentinel lymph nodes; Lymphogenic metastases of certain tumors; Availability of appropriate colloids authorized for human...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics