Simultaneous versus Sequential Intratympanic Steroid Treatment for Severe-to-Profound Sudden Sensorineural Hearing Loss

Yoo, Myung Hoon; Lim, Won Sub; Park, Joo Hyun; Kwon, Joong Keun; Lee, Tae-Hoon; an, Yong-Hwi; Kim, Young-Jin; Kim, Jong Yang; Lim, Hyun Woo; Park, Hong Ju
May 2017
Audiology & Neuro-Otology;May2017, Vol. 21 Issue 6, p399
Academic Journal
journal article
Objectives: Severe-to-profound sudden sensorineural hearing loss (SSNHL) has a poor prognosis. We aimed to compare the efficacy of simultaneous and sequential oral and intratympanic steroids for this condition.Methods: Fifty patients with severe-to-profound SSNHL (>70 dB HL) were included from 7 centers. The simultaneous group (27 patients) received oral and intratympanic steroid injections for 2 weeks. The sequential group (23 patients) was treated with oral steroids for 2 weeks and intratympanic steroids for the subsequent 2 weeks. Pure-tone averages (PTA) and word discrimination scores (WDS) were compared before treatment and 2 weeks and 1 and 2 months after treatment. Treatment outcomes according to the modified American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria were also analyzed.Results: The improvement in PTA and WDS at the 2-week follow-up was 23 ± 21 dB HL and 20 ± 39% in the simultaneous group and 31 ± 29 dB HL and 37 ± 42% in the sequential group; this was not statistically significant. Complete or partial recovery at the 2-week follow-up was observed in 26% of the simultaneous group and 30% of the sequential group; this was also not significant. The improvement in PTA and WDS at the 2-month follow-up was 40 ± 20 dB HL and 37 ± 35% in the simultaneous group and 41 ± 25 dB HL and 48 ± 41% in the sequential group; this was not statistically significant. Complete or partial recovery at the 2-month follow-up was observed in 33% of the simultaneous group and 35% of the sequential group; this was also not significant. Seven patients in the sequential group did not need intratympanic steroid injections for sufficient improvement after oral steroids alone.Conclusions: Simultaneous oral/intratympanic steroid treatment yielded a recovery similar to that produced by sequential treatment. Because the addition of intratympanic steroids can be decided upon based on the improvement after an oral steroid, the sequential regimen can be recommended to avoid unnecessary intratympanic injections.


Related Articles

  • The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial. Kuthubutheen, Jafri; Joglekar, Samidha; Smith, Leah; Friesen, Lendra; Smilsky, Kari; Millman, Tara; Ng, Amy; Shipp, David; Coates, Harvey; Arnoldner, Christoph; Nedzelski, Julian; Chen, Joseph; Lin, Vincent // Audiology & Neuro-Otology;Mar2018, Vol. 22 Issue 4/5, p292 

    Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI).Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80...

  • Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema. Keemss, Kim; Pfaff, Stephanie C.; Born, Matthias; Liebmann, Jörg; Merk, Hans F.; von Felbert, Verena // Dermatology (10188665);Sep2016, Vol. 232 Issue 4, p496 

    Background: Blue light was shown to reduce the activation of T cells and modulate cytokine release in vitro. Therefore, we investigated the efficacy of blue light in the treatment of eczema.Methods: A sample of 21 patients with mild to moderate eczema were locally...

  • Combination Therapy of Etanercept and Fumarates versus Etanercept Monotherapy in Psoriasis: A Randomized Exploratory Study. van Bezooijen, Ji Sun; Balak, Deepak M.W.; van Doorn, Martijn B.a.; Looman, Caspar W.N.; Schreurs, Marco W.J.; Koch, Birgit C.P.; van Gelder, Teun; Prens, Errol P. // Dermatology (10188665);Sep2016, Vol. 232 Issue 4, p407 

    Background: Biologics are a safe and efficacious therapy for psoriasis. The drug survival of biologics may be disappointing, primarily due to loss of efficacy. Therefore, safe combination treatments are sought to improve their clinical response.Objective: To assess the...

  • Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema. A randomised controlled trial. Schmitt, Jochen; Meurer, Michael; Schwanebeck, Uta; Grählert, Xina; Schäkel, Knut; Grahlert, Xina; Schakel, Knut // Dermatology (10188665);Dec2008, Vol. 217 Issue 4, p299 

    Background: Evidence-based treatment algorithms, successfully established for asthma, are missing for atopic eczema (AE).Objectives: To investigate whether treatment according to an evidence-based algorithm is an effective and applicable concept for the management of...

  • Modeling relationships between various domains of hearing aid provision. Meister, Hartmut; Lausberg, Isabel; Kiessling, Jürgen; Von Wedel, Hasso; Walger, Martin; Kiessling, Jürgen // Audiology & Neuro-Otology;May/Jun2003, Vol. 8 Issue 3, p153 

    Various inventories have been developed to quantify the success of hearing aid provision. Though numerous parameters including initial measures (hearing disability, handicap) or 'outcome measures' (e.g. benefit, satisfaction and usage) are recorded, relationships and interactions among them are...

  • Absorbable subcuticular staples versus suture for caesarean section closure: a randomised clinical trial. Madsen, AM; Dow, ML; Tessmer‐Tuck, JA; Lohse, CM; Madsen, A M; Dow, M L; Tessmer-Tuck, J A; Lohse, C M // BJOG: An International Journal of Obstetrics & Gynaecology;Mar2019, Vol. 126 Issue 4, p502 

    Objective: To compare outcomes of efficiency, safety, patient, and surgeon satisfaction between absorbable subcuticular staples and subcuticular suture for caesarean section skin closure.Design: A prospective, randomised, non-blinded, parallel-group trial.Setting:...

  • Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper. Van de Heyning, Paul; Távora-Vieira, Dayse; Mertens, Griet; Van Rompaey, Vincent; Rajan, Gunesh P.; Müller, Joachim; Hempel, John Martin; Leander, Daniel; Polterauer, Daniel; Marx, Mathieu; Usami, Shin-ichi; Kitoh, Ryosuke; Miyagawa, Maiko; Moteki, Hideaki; Smilsky, Kari; Baumgartner, Wolf-Dieter; Keintzel, Thomas Georg; Sprinzl, Georg Mathias; Wolf-Magele, astrid; arndt, Susan // Audiology & Neuro-Otology;May2017, Vol. 21 Issue 6, p391 

    Background: While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment for single-sided deafness (SSD) and asymmetric hearing loss (AHL), in recent years, cochlear implants (CIs) have increasingly become a...

  • Serum Human Beta-Defensin-2 Is a Possible Biomarker for Monitoring Response to JAK Inhibitor in Psoriasis Patients. Jin, Tingting; Sun, Ziwen; Chen, Xixue; Wang, Yun; Li, Ruoyu; Ji, Suzhen; Zhao, Yi // Dermatology (10188665);Oct2017, Vol. 233 Issue 2/3, p164 

    Aims: To analyse the correlation between serum human beta-defensin-2 (hBD-2) levels and response to JAK inhibitor in psoriasis.Methods: We evaluated the psoriasis area and severity index (PASI) and serum hBD-2 levels of 18 psoriasis patients randomized to receive...

  • IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis. Galluzzo, Marco; Boca, andreea Nicoleta; Botti, Elisabetta; Potenza, Concetta; Malara, Giovanna; Malagoli, Piergiorgio; Vesa, Stefan; Chimenti, Sergio; Buzoianu, anca Dana; Talamonti, Marina; Costanzo, antonio // Dermatology (10188665);Apr2016, Vol. 232 Issue 2, p230 

    Background: Psoriasis is characterized by multiple genetic variations. Some of these variations, such as the presence of HLA-Cw6 or TNFAIP3 single-nucleotide polymorphisms (SNPs), have been correlated to the response to biologic treatments.Objective: The aim of our...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics