TITLE

Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3 T MR T1rho quantification

AUTHOR(S)
Zhao, Jian; Li, Xiaojuan; Bolbos, Radu I; Link, Thomas M; Majumdar, Sharmila
PUB. DATE
June 2010
SOURCE
Skeletal Radiology;Jun2010, Vol. 39 Issue 6, p523
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: To quantitatively assess the relationship between bone marrow edema-like lesions (BMELs) and the associated cartilage in knee osteoarthritis (OA) using T(1rho) quantification at 3 T MRI.Materials and Methods: Twenty-four patients with knee OA and 14 control subjects underwent 3 T MRI. Nineteen patients and all control subjects had 1-year follow-up studies. The volume and signal intensity difference of BMELs were calculated. Cartilage degeneration was graded using the cartilage subscore of Whole-Organ MRI Score (WORMS) analysis. Cartilage T(1rho) values were calculated in each compartment as well as in cartilage overlying BMELs (OC) and surrounding cartilage (SC).Results: At baseline, 25 BMELs were found in 16 out of 24 patients. The overall T(1rho) values were significantly higher in patients with BMELs than in those without BMELs. At baseline and follow-up, both T(1rho) values and WORMS cartilage subscore grading were significantly higher in OC than SC. Cartilage T(1rho) increase from baseline to follow-up in OC was significantly higher than that in SC. An increase in T(1rho) values in OC was correlated with signal intensity of BMEL at both baseline and follow-up, but was not correlated with BMEL volume.Conclusions: The results of this study suggest a local spatial correlation between BMELs and more advanced and accelerated cartilage degeneration. MRI T(1rho) quantification in cartilage provides a sensitive tool for evaluating such correlations.
ACCESSION #
119472545

 

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