TITLE

Protective Effect of Platelet Rich Plasma on Experimental Ischemia/Reperfusion Injury in Rat Ovary

AUTHOR(S)
Bakacak, Murat; Bostanci, Mehmet Suhha; İnanc, Fatma; Yaylali, asli; Serin, Salih; attar, Rukset; Yildirim, Gazi; Yildirim, Ozge Kizilkale
PUB. DATE
May 2016
SOURCE
Gynecologic & Obstetric Investigation;May2016, Vol. 81 Issue 3, p225
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background/aims: Ovarian torsion is a common cause of local ischemic damage, reduced follicular activity and infertility. Platelet-rich plasma (PRP) contains growth factors with demonstrated cytoprotective properties; so we evaluated PRP efficacy in a rat ischemia/reperfusion (I/R) model.Methods: Sixty adult female Sprague-Dawley albino rats were randomly assigned to 6 groups of 8 animals each: Sham, Ischemia, I/R, Sham + PRP, I + PRP and I/R + PRP; and the remaining 12 used to prepare PRP. Ischemia groups were subjected to bilateral adnexal torsion for 3 h, while I/R and I/R + PRP groups received subsequent detorsion for 3 h. Intraperitoneal PRP was administered 30 min prior to ischemia (Ischemia + PRP) or reperfusion (I/R + PRP).Results: Total oxidant status (TOS), oxidative stress index (OSI) and total ovarian histopathological scores were higher in Ischemia and I/R groups than in the Sham group (p < 0.05). PRP decreased mean TOS, OSI and histopathological scores in I + PRP and I/R + PRP groups compared to the corresponding Ischemia and I/R groups (p < 0.001). There was a strong correlation between total histopathological score and OSI (r = 0.877, p < 0.001). Peritoneal vascular endothelial growth factor was significantly higher in PRP-treated groups than corresponding untreated groups (p < 0.05).Conclusion: PRP is effective for the prevention of ischemia and reperfusion damage in rat ovary.
ACCESSION #
115853781

 

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