c-MET expression in colorectal adenomas and primary carcinomas with its corresponding metastases

Gayyed, Mariana Fathy; Abd El-Maqsoud, Nehad M. R.; El-Hameed El-Heeny, Amr Abd; Mohammed, Mostafa Fuad
December 2015
Journal of Gastrointestinal Oncology;2015, Vol. 6 Issue 6, p618
Academic Journal
journal article
Background: c-MET plays an important role in tumor proliferation, invasion and metastasis. In this study we examined the expression of c-MET in colorectal adenomas, primary adenocarcinomas and their corresponding lymph node, peritoneal and liver metastases. We correlated our findings with clinicopathological features.Methods: Twenty three cases of colorectal adenoma and 102 cases of primary colorectal carcinoma and their corresponding metastases (44 lymph nodes, 21 peritoneal deposits and 16 liver metastases) were studied to evaluate c-MET expression by immunohistochemistry. For comparison, 12 sections of adjacent healthy colorectal mucosa were examined.Results: Statistically significant differences were present among normal tissues, colorectal adenomas and primary colorectal carcinomas (P=0.011). Normal tissues showed a negative or weak reaction in 66.67% and 33.33% of cases respectively. Expression of c-MET was positive in 47.8% of adenomas. A significant positive association was identified between c-MET high expression and degree of dysplasia (P=0.024). c-MET was highly expressed in 66.7% of primary colorectal carcinoma. Significant positive correlations were detected between c-MET expression and TNM stage (P=0.036), lymph node metastasis (LNM), peritoneal deposits and liver metastasis (P=0.038, P=0.094 and P=0.045, respectively). c-MET expression in metastatic tissues was significantly higher than that of the primary tumor.Conclusions: c-MET expression is gradually up-regulated in the development and progression of colorectal cancer (CRC) from normal epithelium to adenoma to colorectal carcinoma to metastases.


Related Articles

  • γ-Catenin is an independent prognostic marker in early stage colorectal cancer. Jutta Maria Nagel; Kriegl, Lydia; Horst, David; Engel, Jutta; Gautam, Shiva; Mantzoros, Christos S.; Kirchner, Thomas; Göke, Burkhard; Kolligs, Frank Thomas // International Journal of Colorectal Disease;Nov2010, Vol. 25 Issue 11, p1301 

    Purpose: Expression and role of γ-catenin in colorectal carcinogenesis is not well understood. We aimed at characterizing γ-catenin's expression pattern during colorectal carcinogenesis. Methods: The expression pattern of γ-catenin was characterized in adenomas, primary colorectal...

  • Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. Kitamura, S; Kondo, S; Shinomura, Y; Kanayama, S; Miyazaki, Y; Kiyohara, T; Hiraoka, S; Matsuzawa, Y // British Journal of Cancer;9/1/2000, Vol. 83 Issue 5, p668 

    The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including...

  • Enhanced Activity of Meprin-α, a Pro-Migratory and Pro- Angiogenic Protease, in Colorectal Cancer. Lottaz, Daniel; Maurer, Christoph A.; Noël, Agnè s; Blacher, Silvia; Huguenin, Maya; Nievergelt, Alexandra; Niggli, Verena; Kern, Alexander; Müller, Stefan; Seibold, Frank; Friess, Helmut; Becker-Pauly, Christoph; Stöcker, Walter; Sterchi, Erwin E. // PLoS ONE;2011, Vol. 6 Issue 11, p1 

    Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-a levels on tumor progression is not known. We investigated the effect of this protease on cell migration and angiogenesis...

  • CDX-2 immunostaining in primary and secondary ovarian carcinomas.  // Journal of Clinical Pathology;Jun2004, Vol. 57 Issue 6, p641 

    Aims: To assess the value of homeobox protein CDX-2 expression in the distinction between primary orvarian carcinomas and carcinomas metastatic to the ovary. Methods: CDX-2 expression was assessed by immunohistochemistry in 120 serous, 68 endometriod, 24 clear cell, and 16 mucinous carcinomas of...

  • The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models. Bladt, Friedhelm; Friese-Hamim, Manja; Ihling, Christian; Wilm, Claudia; Blaukat, Andree // Cancers;Sep2014, Vol. 6 Issue 3, p1736 

    The mesenchymal-epithelial transition factor (c-Met) is a receptor tyrosine kinase with hepatocyte growth factor (HGF) as its only high-affinity ligand. Aberrant activation of c-Met is associated with many human malignancies, including hepatocellular carcinoma (HCC). We investigated the in vivo...

  • 32/67-kD Laminin Receptor Expression in Human Colonic Neoplasia: Elevated Transcript Levels Correlate With the Degree of Epithelial Dysplasia. Stallmach, Andreas; Orzechowski, Hans-Dieter; Feldmann, Pia; Riecken, Ernst-Otto; Zeitz, Martin; Herbst, Herman // American Journal of Gastroenterology;Nov1999, Vol. 94 Issue 11, p3341 

    OBJECTIVE: The 32/67-kD laminin receptor is thought to be involved in tumor cell migration and metastasis formation, and enhanced expression was observed in human colorectal carcinoma. Our objective was to investigate further the expression of the 32/67-kD laminin receptor RNA in human colonic...

  • Increased matrix metalloproteinase 2 concentration and transcript expression in advanced colorectal carcinomas. Chan, C. C.; Menges, M.; Orzechowski, H.-D.; Orendain, N.; Pistorius, G.; Feifel, G.; Zeitz, M.; Stallmach, A. // International Journal of Colorectal Disease;May2001, Vol. 16 Issue 3, p133 

    Colorectal cancer is one of the most common malignant tumors and entails a relatively poor prognosis. Clinical outcome depends on the extent of local and metastatic tumor spread. Results of in vivo and in vitro studies suggest that the balance between matrix metalloproteinases (MMPs) and their...

  • The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. Kaimaktchiev, Vassil; Terracciano, Luigi; Tornillo, Luigi; Spichtin, Hanspeter; Stoios, Dimitra; Bundi, Marcel; Korcheva, Veselina; Mirlacher, Martina; Loda, Massimo; Sauter, Guido; Corless, Christopher L. // Modern Pathology;Nov2004, Vol. 17 Issue 11, p1392 

    CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestines. Based on recent studies, CDX2 expression is immunohistochemically detectable in normal colonic enterocytes and is retained in most, but not all, colorectal...

  • The Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to Carcinoma. Abdulamir, A. S.; Hafidh, R. R.; Mahdi, L. K.; Al-jeboori, T. R.; Abubaker, F.; Abbas, K. A. // American Journal of Immunology;2008, Vol. 4 Issue 2, p14 

    This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics