Xenotransplantation: Assessing the unknowns

Tackaberry, Eilleen S.; Ganz, Peter R.
July 1998
CMAJ: Canadian Medical Association Journal;07/14/98, Vol. 159 Issue 1, p41
Academic Journal
Editorial. Discusses the potential benefits and risks of proceeding with clinical xenotransplantation trials. The idea of using animal cells; The animal considered to be the best xenograft source; Certain misgivings xenotransplantation has given rise to; The dilemma of whether investigators should proceed with further trials using animals.


Related Articles

  • Porcine affairs. Donnelly, Strachan // Hastings Center Report;Sep/Oct95, Vol. 25 Issue 5, preceding p1 

    Comments on topics discussed during a conference on ethical issues in animal biotechnology co-organized by nonprofit organization the Hastings Center. Scientific and ethical complexities of xenotransplantation; Transgenic fashioning of pigs to serve as organ donors; Instant `xenotransplantation...

  • Overcoming Hyperacute Xenograft Rejection With Transgenic Animals. Goodman, D.J.; Pearse, M.J.; d'Apice, A.J.F. // BioDrugs;1998, Vol. 9 Issue 3, p219 

    Xenotransplantation offers an alternative source of organs to solve the current critical shortage of donor organs required for patients with end-stage kidney, heart and liver disease. For social, ethical and logistical purposes, pigs appear to be the most appropriate donor animal. The...

  • Arguments for the ethical permissibility of transgenic xenografting. Bramstedt, Katrina A // Gene Therapy;Apr2000, Vol. 7 Issue 8, p633 

    Editorial. Discusses the biological and ethical aspects of transgenic xenografting using animals as organ donors. Concept of animal rights; Permissibility of genetic manipulation in animals; Infection risk associated with xenotransplantation.

  • In brief. McGovern, Celeste // Report / Newsmagazine (National Edition);9/23/2002, Vol. 29 Issue 18, p50 

    Presents news briefs relating to science as of September 23, 2002. Cloning of livestock in the meat industry; Outlook for the production of transgenic animals with DNA mixed from different species; Question of whether xenotransplantation could create an uncontrollable human epidemic.

  • So far, so good... Coghlan, Andy // New Scientist;08/08/98, Vol. 159 Issue 2146, p4 

    Reports that screening samples from patients exposed to pig tissue provide the first compelling evidence that dormant pig viruses do not spread to humans. How this effects clinical xenotransplant trials; Porcine endogenous retroviruses; A workshop on pig viruses organized by the United Kingdom...

  • Animal organs for human patients? Palca, Joseph // Hastings Center Report;Sep/Oct95, Vol. 25 Issue 5, p4 

    Discusses xenotransplantation and its moral implications. History; United States Food and Drug Administration's stance on the issue; Controversy over the Ildstad-Volberding protocol.

  • Xenografts raise questions about cancer virus transfer to humans. Randal, Judith // JNCI: Journal of the National Cancer Institute;02/18/98, Vol. 90 Issue 4, p264 

    Presents information on xeno-transplants, highlighting the use of pigs' organs, while emphasizing two viruses which lurk in these organs. Identification of the viruses; Doctors' concerns with regarding these viruses; Reference to information from John Coffin, a doctor at the Tufts University in...

  • Hancock xenograft for right ventricular outflow tract reconstruction - 28 years surgical experience.  // Cardiology in the Young;May2006 Supplement, Vol. 16 Issue S2, p6 

    The article presents an abstract of the article "Hancock Xenograft for Right Ventricular Outflow Tract reconstruction - 28 Years Surgical Experience," by A.F. Maizza, V.S. Luisi,and M. Bernabei.

  • Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Stojdl, David F.; Lichty, Brian; Knowles, Shane; Marius, Ricardo; Atkins, Harold; Sonenberg, Nahum; Bell, John C. // Nature Medicine;Jul2000, Vol. 6 Issue 7, p821 

    Interferons are circulating factors that bind to cell surface receptors, activating a signaling cascade, ultimately leading to both an antiviral response and an induction of growth inhibitory and/or apoptotic signals in normal and tumor cells. Attempts to exploit the ability of interferons to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics