Nerve growth factor, D2 receptor isoforms, and pituitary tumors

Missale, Cristina
December 2012
Endocrine (1355008X);Dec2012, Vol. 42 Issue 3, p466
Academic Journal
The author discusses the effects of dopamine (DA) on lactotrope cell proliferation and differentiation. He mentions that nerve growth factor (NGF) promotes proliferation and differentiation of lactotrope cells during pituitary development in vitro. He adds that finding of two binding proteins that regulate D2R pre-mRNA splicing may force the splicing toward the D2 receptors (D2S) isoform in a pituitary tumor-specific manner.


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