Classifying Acute Leukemias
Tags: LEUKEMIA; CYTOGENETICS
Related Articles
- Cytogenetic & molecular analyses in adult chronic myelogenous leukaemia patients in north India. Anand, Maninder Singh; Varma, Neelam; Varma, Subhash; Rana, Kamer Singh; Malhotra, Pankaj // Indian Journal of Medical Research;Jan2012, p42
Background & objectives: Chronic myelogenous leukaemia (CML) is the commonest leukaemia in Asia. There is a paucity data on cytogenetic and molecular analyses of Indian CML patients. This apparently reflects the low availability of cytogenetic and molecular techniques in our country. This study...
- An extremely delayed cytogenetic response to interferon-a in a patient with chronic myeloid leukaemia. Whiteway, A J; Reid, C D L; Cross, N C P // Leukemia (08876924);Apr97, Vol. 11 Issue 4, p614
In chronic myeloid leukaemia (CML), treatment with interferon alpha IFN-a results in loss of the Ph' chromosome in a significant proportion of patients. Most cytogenetic responses occur early at a median of 9 months after initiation of treatment and failure to detect a cytogenetic response...
- Development of an interphase fluorescent in situ hybridization (FISH) test to detect t(8;21) in AML patients. Hagemeijer, A; de Klein, A; Wijsman, J; van Meerten, E; de Greef, G E; Sacchi, N // Leukemia (08876924);Jan98, Vol. 12 Issue 1, p96
The translocation (8;21) is a chromosome abnormality associated with acute myeloid leukemia (AML). As a consequence of the translocation the AML1 (CBFA2) gene in the 21q22 region is fused to the ETO(CDR,MTG8) gene in the 8q22 region, resulting in one transcriptionally active gene on the 8q-...
- The first report of a Philadelphia chromosome and BCR/ABL rearrangement positive myeloproliferative disorder in a child with thrombocythemia. Anguita, E; Valverde, F; Gonz�lez, F A; Gil, C; Mateo, M; Ferro, M T; Villegas, A // Leukemia (08876924);Mar98, Vol. 12 Issue 3, p442
Focuses on chronic myelogenous leukemia characterized by the presence of Philadelphia chromosome with reference to a case study. Analysis of the relationship of essential thrombocythemia with the chromosome; Highlights of the case in reference; Cytogenetic analysis of blood and bone marrow...
- Quantitation of minimal residual disease in acute myelogenous leukemia and myelodysplastic syndromes in complete remission by molecular cytogenetics of progenitor cells. Engel, H; Drach, J; Keyhani, A; Jiang, S; Van, N T; Kimmel, M; Sanchez-Williams, G; Goodacre, A; Andreeff, M // Leukemia (08876924);Apr99, Vol. 13 Issue 4, p568
Detection of karyotypic clonal abnormalities are prognostically useful in patients with acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS), but cytogenetic methods are not sensitive enough to detect low numbers of residual leukemic cells in patients who have achieved complete...
- Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21. Melnick, A; Fruchtman, S; Zelent, A; Liu, M; Huang, Q; Boczkowska, B; Calasanz, M J; Fernandez, A; Licht, J D; Najfeld, V // Leukemia (08876924);Oct99, Vol. 13 Issue 10, p1534
Chromosomal translocations are frequently linked to multiple hematological malignancies. The study of the resulting abnormal gene products has led to fundamental advances in the understanding of cancer biology. This is the first report of t(2;15)(p23;q22) and t(2;17)(p23;q21) translocations in...
- Molecular Cytogenetics Investigation of the Telomeres in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion. Krejc�, Katerina; Stentoft, Jesper; Koch, J�rn // Neoplasia;Dec99, Vol. 1 Issue 6, p492
We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus -negative cells, we found generally...
- Use of dual-color interphase FISH for the detection of inv(16) in acute myeloid leukemia at diagnosis, relapse and during follow-up: a study of 23 patients. Mancini, M; Cedrone, M; Diverio, D; Emanuel, B; Stul, M; Vranckx, H; Brama, M; De Cuia, M R; Nanni, M; Fazi, F; Mecucci, C; Alimena, G; Hagemeijer, A // Leukemia (08876924);Mar2000, Vol. 14 Issue 3, p364
The value of dual-color fluorescence in situ hybridization (FISH) for the detection of inv(16), using two contigs of cosmid probes mapping on both sides of the chromosome 16p breakpoint region, was evaluated in 23 acute myeloid leukemias (AML) in different phases of the disease. At diagnosis...
- Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization. Guti�rrez, N C; Hern�ndez, J M; Garc�a, J L; Ca�izo, M C; Gonz�lez, M; Hern�ndez, J; Gonz�lez, M B; Garc�a-Marcos, M A; San Miguel, J F // Leukemia (08876924);May2001, Vol. 15 Issue 5, p840
To analyze the genomic differences between multiple myeloma (MM) and plasma cell leukemia (PCL), a total of 30 cases were studied by comparative genomic hybridization (CGH). In five cases with a low proportion of plasma cells (PC) in bone marrow, an enrichment of PC was performed by using...
