Retinitis pigmentosa: A brief overview

Natarajan, S.
September 2011
Indian Journal of Ophthalmology;Sep2011, Vol. 59 Issue 5, p343
Academic Journal
The author reflects on the implication and the treatment for retinitis pigmentosa (RP) which is a hereditary disorder of the photoreceptors and retinal pigment epithelium (RPE). He states that RP only affects the eye, in which vision loss in RP is due to progressive retinal degeneration in cases such as cystoid macular edema and posterior subcapsular cataract. Furthermore, he mentions that treatment using growth factors can slow the progression of RP.


Related Articles

  • Rare diseases: Retinitis pigmentosa.  // GP: General Practitioner;9/5/2012, p30 

    The article reports on Retinitis Pigmentosa, one of the inherited diseases of the retina, that lead to a progressive reduction in vision. Presentation may involve impaired night vision, a tendency to trip over things, or can follow a road accident. There is no definite treatment, though...

  • Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa.  // Molecular Neurodegeneration;2011, Vol. 6 Issue 1, p56 

    The article reports on a study related to Retinitis pigmentosa (RP), an inherited eye disease characterized by the progressive degeneration of rod photoreceptor cells. The study suggests that distinct mutations in Prpf31 can lead to photoreceptor degeneration through different mechanisms, by...

  • Retinal Blinding Disorders and Gene Therapy - Molecular and Clinical Aspects. Lorenz, Birgit; Preising, Markus; Stieger, Knut // Current Gene Therapy;Oct2010, Vol. 10 Issue 5, p350 

    No abstract available.

  • Good Epidemiologic Practice in Retinitis Pigmentosa: From Phenotyping to Biobanking. Chizzolini, Marzio; Galan, Alessandro; Milan, Elisabeth; Sebastiani, Adolfo; Costagliola, Ciro; Parmeggiani, Francesco // Current Genomics;Jun2011, Vol. 12 Issue 4, p260 

    Inherited retinal dystrophies, such as retinitis pigmentosa (RP), include a group of relatively rare hereditary diseases caused by mutations in genes that code for proteins involved in the maintenance and function of the photoreceptor cells (cones and rods). The different forms of RP consist of...

  • RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction. MURGA-ZAMALLOA, CARLOS A.; SWAROOP, ANAND; KHANNA, HEMANT // Journal of Genetics;Dec2009, Vol. 88 Issue 4, p399 

    Dysfunction of primary cilia due to mutations in cilia-centrosomal proteins is associated with pleiotropic disorders. The primary (or sensory) cilium of photoreceptors mediates polarized trafficking of proteins for efficient phototransduction. Retinitis pigmentosa GTPase regulator (RPGR) is a...

  • Gene therapy successfully treats blindness. Sheth, Parul R. // Current Science (00113891);7/10/2008, Vol. 95 Issue 1, p17 

    The article presents a study bringing the foundation for gene therapy approaches to the treatment of Leber's congenital amaurosis (LCA) and other forms of retinal degeneration. The study sponsored by the Centre for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia,...

  • Apoptosis: A Potential Therapeutic Target for Retinal Degenerations. Doonan, Francesca; Cotter, Thomas G. // Current Neurovascular Research;Jan2004, Vol. 1 Issue 1, p41 

    Many retinal degenerations both inherited and induced are characterized by a loss of vision that is associated with death of photoreceptors. Inherited retinal diseases, which include Retinitis Pigmentosa (RP), form the largest single cause of blindness in the developed world. The genetics of RP...

  • Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat. Ray, Aditi; Sun, Gerald J.; Chan, Leanne; Grzywacz, Norberto M.; Weiland, James; Eun-Jin Lee // Cell & Tissue Research;Mar2010, Vol. 339 Issue 3, p481 

    The S334ter-line-3 rat is a transgenic model of retinal degeneration developed to express a rhodopsin mutation similar to that found in human retinitis pigmentosa (RP) patients. Previous studies have focused on physiological changes in retinal cells and higher centers of the visual system with...

  • A Large Animal Model for CNGB1 Autosomal Recessive Retinitis Pigmentosa. Winkler, Paige A.; Ekenstedt, Kari J.; Occelli, Laurence M.; Frattaroli, Anton V.; Bartoe, Joshua T.; Venta, Patrick J.; Petersen-Jones, Simon M. // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition. We investigated PRA in the Papillon breed of dog using homozygosity mapping and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics