Pros and cons of dabigatran

Cheng, Christine M.; McCurdy, Megan R.; Wong, Heather A.; Kayser, Steven R.
August 2011
American Journal of Health-System Pharmacy;8/15/2011, Vol. 68 Issue 16, p1495
Academic Journal
In this article the author discusses the pros and cons of dabigatran etexilate which is the first oral direct thrombin inhibitor and the first oral anticoagulant. It offers details on the limitations of dabigatran and suggests avoiding its use by patients who are unable to swallow the whole capsule. Also mentioned is the RE-LY trial that recommends dabigatran for patients with poor quality of International Normalized Ratio (INR) control, and in whom medication adherence is expected to be high.


Related Articles

  • Tinzaparin sodium overdose.  // Reactions Weekly;Mar2014, Vol. 1490 Issue 1, p35 

    The article presents a case report of a 69-year-old woman who developed deranged coagulation parameters following an intentional overdose of tinzaparin sodium.

  • Cortical Blindness and Bilateral Occipital Haemorrhage due to Warfarin Overdose. Özgür Erdoðan, Mehmet; Yorulmaz, Rasim; Tayfur, Ýsmail; Giritli, Özlem; Telli Erdoðan, Seçil // Journal of Academic Emergency Medicine Case Reports / Akademik A;2013, Vol. 4 Issue 2, p73 

    Bleeding is a common complication of anticoagulant agents. Rising numbers of patients requiring warfarin, as well as increasing long term use, causes some haemorraghic complications. Intracerebral haemorrhage is one of these complications. An 88 year old patient was admitted to our emergency...

  • ED patients may be overdosing on meds.  // ED Nursing;12/1/2011, p20 

    The article presents the insights of emergency department supervisor (ED) Kimberly Barker on the reason why the approach of taking a pill whenever the patient has a soar throat is harmful. Barker says that the bladder infection will not be killed by taking one pill like Zithromax , but instead...

  • Anticoagulant errors could kill your next ED patient: Make changes now.  // ED Nursing;Oct2007, Vol. 10 Issue 12, p133 

    When administering anticoagulant therapy, if you overdose, underdose, or fail to recognize signs and symptoms of bleeding, your patient can be seriously harmed or killed. Reducing the likelihood of patient harm involving anticoagulant therapy is one of the new National Patient Safety Goals for...

  • Warfarin overdose.  // Reactions Weekly;5/19/2007, Issue 1152, p27 

    The article describes the case of an older man who developed endotension after receiving an inadvertent overdose of warfarin. Endotension characterizes by increasing aneurysm sac diameter in the absence of an endoleak. The patient experienced dyspnea, subconjunctival hemorrhages and fatigue...

  • Spinal Epidural Haematoma Related to Oral Anticoagulant Overdose A Case Report. Bayir, A.; Akilli, B.; Cengiz, S. L. // Neuroradiology Journal;Jun2008, Vol. 21 Issue 3, p368 

    The most important complication during the treatment of oral anticoagulants is bleeding and it is seen most commonly in the skin, urinary system, gastrointestinal tract and central nervous system. Spinal epidural bleeding related to oral coagulant overdose is a rare complication and it may...

  • Dabigatran etexilate overdose.  // Reactions Weekly;Aug2015, Vol. 1563 Issue 1, p74 

    The article presents a case study of an 81-year-old woman who experienced abnormal coagulation tests following an overdosage of dabigatran etexilate for non-valvular atrial fibrillation and moderate chronic renal impairment.

  • Paracetamol tablets sold in excess of legislation limits.  // Nursing Standard;10/11/2006, Vol. 21 Issue 5, p14 

    The article presents a research conducted by the London researchers on the patients' adherence to the limitation of the availability of paracetamol in London, England. It is inferred that due to several fatal poisonings, paracetamol's pack sizes and its availability to the market were reduced....

  • Rivaroxaban: Another Warfarin Replacement.  // Travel Medicine Advisor;Jan2011 Supplement, p1 

    The article offers news briefs related to pharmacology in the U.S. A study shows that rivaroxaban, an oral drug factor Xa inhibitor, is as effective as warfarin in preventing stroke and blood clots in patients with nonvalvular atrial fibrillation. A study published in "Annals of Internal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics