TITLE

Metabolic modulation in heart failure: high time for a difinitive clinical trial

AUTHOR(S)
Ashrafian, Houman; Neubauer, Stefan
PUB. DATE
February 2011
SOURCE
Heart;Feb2011, Vol. 97 Issue 4, p267
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The authors emphasize the need for a definitive clinical trial on the benefit of metabolic modulation in heart failure (HF) in relation to a study by D. Gao and colleagues within the issue. Based on the study, left ventricular ejection fraction is improved by trimetazidine. Research have shown that beneficial metabolic effects in HF may result from increased fatty acid utilisation. The impediment posed by high standards for clinical and regulatory approval of such drugs to their use in HF is noted.
ACCESSION #
60961430

 

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