Aldosterone Antagonists � Last Man Standing?

Armstrong, Paul W.
January 2011
New England Journal of Medicine;1/6/2011, Vol. 364 Issue 1, p79
Academic Journal
The author reflects on aldosterone antagonists in the treatment of heart failure. It says that in the turn of the millennium, there are four cardiac medicines developed before 1960 that survived namely aspirin, digoxin, warfarin and spironolactone. It highlights two studies whose findings have made aldosterone-receptor blockade to become part of recommended therapy in patients with functional class III or IV heart failure and those recovering from acute myocardial infarction with complicating left ventricular dysfunction.


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