Editorial: Antibiotics Earlier, IBD Later?

De Vroey, Bénédicte; De Cassan, Chiara; Gower-Rousseau, Corinne; Colombel, Jean-Frédéric
December 2010
American Journal of Gastroenterology;Dec2010, Vol. 105 Issue 12, p2693
Academic Journal
Increasing evidence accumulates for a role of environmental factors in the onset of inflammatory bowel diseases (IBD). Among them, factors that might disturb the gut microflora hold an important place. As such, antibiotics deserve a special attention, and a possible association between their use, particularly during childhood, and the development of IBD, has been assessed by several authors since 1987. Results, conclusions, and possible impact of their observations, as well as perspectives for the future, are discussed here, in view of the article published in this issue of the Journal by Shaw et al.


Related Articles

  • Interleukin-1 β-induced decrease of NHE3 interacting protein PDZK1, as well as sh-RNA-mediated PDZK1 knockdown, is associated with NHE3 dysfunction in the colonic epithelial cell line Caco-2bbe. Chodisetti, G.; Luo, M.; Klöpper, A.; Riederer, B.; He, P.; Yun, C. C.; Yeruva, S.; Seidler, U. // Proceedings of the Physiological Society;2013, p503P 

    Background: Inflammatory bowel disease (IBD) is a major gastrointestinal disease with diarrhea being a leading symptom. The pathophysiology of inflammatory diarrhea is multifacto-rial and still ill understood. We have previously reported a dysfunction of the major intestinal sodium absorptive...

  • Bifidobacterium infantis strains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. Osman, Nadia; Adawi, Diya; Molin, Goran; Ahrne, Siv; Berggren, Anna; Jeppsson, Bengt // BMC Gastroenterology;2006, Vol. 6, p1 

    Background: Pathogenesis of inflammatory bowel disease is thought to be through different factors and there is a relationship between the gut flora and the risk of its development. Probiotics can manipulate the microflora in chronic inflammation and may be effective in treating inflammation....

  • The Immunological Basis of Inflammatory Bowel Disease. Silva, Francesca A. R.; Rodrigues, Bruno L.; Ayrizono, Maria de Lourdes S.; Leal, Raquel F. // Gastroenterology Research & Practice;12/14/2016, p1 

    Inflammatory bowel diseases (IBDs) are chronic ailments, Crohn’s disease and ulcerative colitis being the most important. These diseases present an inflammatory profile and they differ according to pathophysiology, the affected area in the gastrointestinal tract, and the depth of the...

  • Inflammatory Bowel Disease in Asia. Ng, Siew C. // Gastroenterology & Hepatology;Jan2013, Vol. 9 Issue 1, p28 

    An interview with assistant professor Siew C. Ng of Chinese University of Hong Kong is presented. Ng says that the incidence and prevalence of inflammatory bowel disease (IBD) are lower in Asia compare to Western Countries. She states that the rising prevalence of IBD in Asia is due to several...

  • Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. Moehle, Christoph; Ackermann, Nikolaus; Langmann, Thomas; Aslanidis, Charalampos; Kel, Alexander; Kel-Margoulis, Olga; Schmitz-Madry, Anna; Zahn, Alexandra; Stremmel, Wolfgang; Schmitz, Gerd // Journal of Molecular Medicine;Dec2006, Vol. 84 Issue 12, p1055 

    Loss of intestinal mucosa integrity is an important factor in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to characterize expression changes and allelic variants of genes related to intestinal epithelial barrier function in this disease. Therefore, ileal and...

  • Intestinal bile acid physiology and pathophysiology. Martínez-Augustin, Olga; de Medina, Fermín Sánchez; Karvar, Serhan // World Journal of Gastroenterology;10/7/2008, Vol. 14 Issue 37, p5630 

    Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely...

  • Epidemiologic Insights into Stone Disease as a Systemic Disorder. Curhan, Gary C. // AIP Conference Proceedings;2007, Vol. 900 Issue 1, p88 

    Examining the epidemiology of stone disease can provide insight into etiology. There is a growing body of evidence that stone disease is not simply a disorder of the kidney. In fact, nephrolithiasis is clearly a systemic disorder. Conditions associated with stone disease include the classic ones...

  • Enteropathic spondyloarthropathy: A common genetic background with inflammatory bowel disease? Colombo, Elisabetta; Latiano, Anna; Palmieri, Orazio; Bossa, Fabrizio; Andriulli, Angelo; Annese, Vito; Thompson, Nick P.; Stone, Christian D. // World Journal of Gastroenterology;5/28/2009, Vol. 15 Issue 20, p2456 

    The association between spondyloarthropathy and inflammatory bowel disease (IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies. Most studies indicate that as many as 10%-15% of cases of IBD are complicated by...

  • MC-12, an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis. Nengtai Ouyang; Caihua Zhu; Dingying Zhou; Ting Nie; Go, Mae F.; Richards, Robert J.; Rigas, Basil // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    Annexin A1 (ANXA1) inhibits NF- κB, a key regulator of inflammation, the common pathophysiological mechanism of inflammatory bowel diseases (IBD). MC-12, an ANXA1-based tripeptide, suppresses NF-κB activation. Here, we determined the efficacy of MC-12 in the control of IBD. Mice with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics