Dihydrotestosterone: Hormone or Autocrine--Paracrine Signal?

Swerdloff, Ronald S.; Wang, Christina
November 2010
Annals of Internal Medicine;11/16/2010, Vol. 153 Issue 10, p678
Academic Journal
The authors reflect on the risk-benefit profile of testosterone replacement. They argue that the findings offer insights on the possible efficacy of future synthetic androgen receptor modulators which will share the anabolic effects on muscle and fat as well as the sparing effects on the prostate. An overview of the randomized and controlled trial that studied the long term effects of dihydrotestosterone (DHT) treatment on prostate growth is offered.


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