TITLE

Genome-wide association studies - A summary for the clinical gastroenterologist

AUTHOR(S)
Melum, Espen; Franke, Andre; Karlsen, Tom H.; Shu Zheng
PUB. DATE
November 2009
SOURCE
World Journal of Gastroenterology;11/21/2009, Vol. 15 Issue 43, p5377
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
Genome-wide association studies (GWAS) have been applied to various gastrointestinal and liver diseases in recent years. A large number of susceptibility genes and key biological pathways in disease development have been identified. So far, studies in inflammatory bowel diseases, and in particular Crohn's disease, have been especially successful in defining new susceptibility loci using the GWAS design. The identification of associations related to autophagy as well as several genes involved in immunological response will be important to future research on Crohn's disease. In this review, key methodological aspects of GWAS, the importance of proper cohort collection, genotyping issues and statistical methods are summarized. Ways of addressing the shortcomings of the GWAS design, when it comes to rare variants, are also discussed. For each of the relevant conditions, findings from the various GWAS are summarized with a focus on the affected biological systems.
ACCESSION #
45308139

 

Related Articles

  • Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn's disease patients. Csöngei, Veronika; Járomi, Luca; Sáfrány, Enikõ; Sipeky, Csilla; Magyari, Lili; Polgár, Noémi; Bene, Judit; Sarlós, Patrícia; Lakner, Lilla; Baricza, Eszter; Szabó, Melinda; Rappai, Gábor; Melegh, Béla // International Journal of Colorectal Disease;Sep2011, Vol. 26 Issue 9, p1119 

    Backgrounds and aims: The IGR2198a_1 and IGR2096a_1 variants of the IBD5 region were found to be associated with Crohn's disease (CD) in the Hungarian population, while IGR2230a_1 does not seem to confer risk for the disease. In the present study, our aim was to investigate the statistical...

  • The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. De Jager, P. L.; Franchimont, D.; Waliszewska, A.; Bitton, A.; Cohen, A.; Langelier, D.; Belaiche, J.; Vermeire, S.; Farwell, L.; Goris, A.; Libioulle, C.; Jani, N.; Dassopoulos, T.; Bromfield, G. P.; Dubois, B.; Cho, J. H.; Brant, S. R.; Duerr, R. H.; Yang, H.; Rotter, J. I. // Genes & Immunity;Jul2007, Vol. 8 Issue 5, p387 

    The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD...

  • Association between CTLA-4 Gene Promoter (49 A/G) in Exon 1 Polymorphisms and Inflammatory Bowel Disease in the Tunisian Population. Alaya, Walid Ben; Sfar, Imen; Aouadi, Houda; Jendoubi, Saloua; Najjar, Tawfik; Filali, Azza; Gorgi, Yousr; Abdallah, Taieb Ben; Mouelhi, Leila; Matri, Samira; Ayed, Khaled // Saudi Journal of Gastroenterology;Jan2009, Vol. 15 Issue 1, p29 

    Background/Aim: To investigate the possible association between the polymorphism of the CTLA-4 exon 1 +49 A/G and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population. Methods: The +49 A/G dimorphism was analyzed in 119 patients with CD, 65 patients with...

  • ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity. Fowler, Elizabeth V.; Doecke, James; Simms, Lisa A.; Zhen Zhen Zhao; Webb, Penelope M.; Hayward, Nicholas K.; Whiteman, David C.; Florin, Timothy H.; Montgomery, Grant W.; Cavanaugh, Juleen A.; Radford-Smith, Graham L. // American Journal of Gastroenterology;Oct2008, Vol. 103 Issue 10, p2519 

    OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of inflammatory bowel disease (IBD), representing a significant health-care burden. A variant in the autophagy gene ATG16L1 (T300A) has been newly identified as a CD susceptibility locus by genome-wide...

  • New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort. Papp, Maria; Altorjay, Istvan; Dotan, Nir; Palatka, Karoly; Foldi, Ildiko; Tumpek, Judit; Sipka, Sandor; Udvardy, Miklos; Dinya, Tamas; Lakatos, Laszlo; Kovacs, Agota; Molnar, Tamas; Tulassay, Zsolt; Miheller, Pal; Norman, Gary L.; Szamosi, Tamas; Papp, Janos; Lakatos, Peter L. // American Journal of Gastroenterology;Mar2008, Vol. 103 Issue 3, p665 

    BACKGROUND: Antibodies to Saccharomyces cerevisiae ( S. cerevisiae) (ASCA) and porin protein-C of Escherichia coli (anti-OmpC) are associated with disease phenotype and may be of diagnostic importance in inflammatory bowel diseases (IBD). Our aim was to determine whether a panel of new...

  • Chemokines in colitis: microRNA control. Roy, Ishan; Veldkamp, Christopher T.; Volkman, Brian F.; Dwinell, Michael B. // Gut;Aug2014, Vol. 63 Issue 8, p1202 

    The article presents comments of authors on the article "miR-141 Regulates Colonic Leukocytic Trafficking by Targeting CXCL12ß During Murine Colitis and Human Crohn's Disease," by researcher Z. Huang and collegues. Topics discussed include roles of miRNAs in the pathogenesis of Inflammatory...

  • Structural Modification of the Gastrointestinal Epithelium during Immune-Dependent Granulomatosis. Nepomnyashchikh, D. L.; Burkovskaya, V. A.; Aidagulova, S. V.; Bakarev, M. A.; Postnikova, O. A.; Kapustina, V. I.; Nokhrina, Zh. V.; Vinogradova, E. V. // Bulletin of Experimental Biology & Medicine;Feb2011, Vol. 150 Issue 4, p490 

    We present results of pathomorphological study of the mucosa epithelium in various parts of the gastrointestinal tract in Crohn's disease. Particular attention was paid to structural transformation of epithelial cells. Barrier dysfunction of the gastrointestinal mucosa was shown to be one of the...

  • PORTAL HYPERTENSIVE GASTROPATHY DUE TO CHRONIC PORTAL VEIN OCCLUSION IN CROHN'S DISEASE. Yada, Shinichiro; Hizawa, Kazuoki; Aoyagi, Kunihiko; Hashizume, Makoto; Matsumoto, Takayuki; Koga, Hideki; Fujishima, Masatoshi // American Journal of Gastroenterology;Aug1998, Vol. 93 Issue 8, p1376 

    We report a case of portal hypertensive gastropathy due to chronic portal vein occlusion, occurring in a patient with Crohn's disease.

  • Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage. D Foell // Gut;Jun2009, Vol. 58 Issue 6, p859 

    It is a common experience that gastrointestinal symptoms urge us to differentiate inflammatory bowel disease (IBD) from functional disorders. Furthermore, in patients with proven IBD the disease activity has to be accurately monitored. Faecal markers of neutrophil influx into the mucosa are...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics