Off with the label and on the Avastin bandwagon: Why now and how far?

Gopal, K. S. Santhan
September 2009
Indian Journal of Ophthalmology;Sep2009, Vol. 57 Issue 4, p253
Academic Journal
The article presents the author's views about the "off label" use of avastin by ophthalmologists. The author says that the ophthalmologist must be aware of the legal, financial, industrial and ethical implications of its use. The author further says that avastin certainly looks the best option from the point of view of all concerned including patient, physician and the funding agencies.


Related Articles

  • A Phase 3 Trial of Bevacizumab in Ovarian Cancer. Perren, Timothy J.; Swart, Ann Marie; Pfisterer, Jacobus; Ledermann, Jonathan A.; Pujade-Lauraine, Eric; Kristensen, Gunnar; Carey, Mark S.; Beale, Philip; Cervantes, Andr�s; Kurzeder, Christian; Bois, Andreas du; Sehouli, Jalid; Kimmig, Rainer; St�hle, Anne; Collinson, Fiona; Essapen, Sharadah; Gourley, Charlie; Lortholary, Alain; Selle, Fr�d�ric; Mirza, Mansoor R. // New England Journal of Medicine;12/29/2011, Vol. 365 Issue 26, p2484 

    Background: Angiogenesis plays a role in the biology of ovarian cancer. We examined the effect of bevacizumab, the vascular endothelial growth factor inhibitor, on survival in women with this disease. Methods: We randomly assigned women with ovarian cancer to carboplatin (area under the curve, 5...

  • Toxicities of Targeted Agents in Advanced Renal Cell Carcinoma. Patel, Priti; Srinivas, Sandy // Current Clinical Pharmacology;Aug2011, Vol. 6 Issue 3, p181 

    The targeted therapies available to treat metastatic kidney cancer include vascular endothelial growth factor (VEGF) inhibitors, bevacizumab, sorafenib, sunitinib, pazopanib, and the mTor inhibitors temsirolimus and everolimus. These agents have significantly improved patient outcomes but are...

  • Pneumatic displacement with intravitreal bevacizumab for massive submacular hemorrhage due to polypoidal choroidal vasculopathy. Masayasu Kitahashi; Takayuki Baba; Madoka Sakurai; Hirotaka Yokouchi; Mariko Kubota-Taniai; Yoshinori Mitamura; Shuichi Yamamot // Clinical Ophthalmology;2014, Vol. 8, p485 

    Background: The purpose of this study was to compare the effectiveness of pneumatic displacement combined with intravitreal bevacizumab (IVB) with that of pneumatic displacement (PD) alone to treat massive submacular hemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV). Methods:...

  • Basic steps reduce endophthalmitis risk from anti-VEGF injections. Hasson, Matt // Ocular Surgery News;9/25/2008, Vol. 26 Issue 18, p38 

    The article discusses a research on endophthalmitis associated with intravitreal anti-vascular endothelial growth factor (VEGF) therapy injections. It references a study by Richard F. Spaide and colleagues, published in the "American Journal of Ophthalmology." The study showed that the incidence...

  • Intravitreal bevacizumab for choroidal neovascularisation associated with pseudoxanthoma elasticum. Finger, R. P.; Charbel Issa, P.; Ladewig, M.; Holz, F. G.; Scholl, H. P. N. // British Journal of Ophthalmology;Apr2008, Vol. 92 Issue 4, p483 

    Purpose: To investigate the efficacy of intravitreal bevacizumab injections for treating choroidal neovascularisation (CNV) secondary to pseudoxanthoma elasticum (PXE). Methods: Patients with active CNV due to PXE received intravitreal bevacizumab (1.5 mg) and were reviewed at monthly intervals....

  • Optimal Protocols for the Anti-VEGF Tumor Treatment. Anita, S.; Hritonenko, N.; Marinoschi, G.; Swierniak, A.; Poleszczuk, J.; Piotrowska, M. J.; Foryś, U. // Mathematical Modelling of Natural Phenomena;Jul2014, Vol. 9 Issue 4, p204 

    Cancer treatment using the antiangiogenic agents targets the evolution of the tumor vasculature. The aim is to significantly reduce supplies of oxygen and nutrients, and thus starve the tumor and induce its regression. In the paper we consider well established family of tumor angiogenesis models...

  • Bevacizumab.  // Reactions Weekly;4/11/2009, Issue 1247/1248, p8 

    The article describes the case of a 51-year-old man with metastatic colorectal cancer who developed papules on his neck 2 months after taking bevacizumab. The lesions were mildly pruritic and showed adherent central keratotic plugs. Her skin biopsy revealed transepidermal collagen elimination...

  • Effects of bevacizumab on plasma concentration of irinotecan and its metabolites in advanced colorectal cancer patients receiving FOLFIRI with bevacizumab as second-line chemotherapy. Horita, Yosuke; Yamada, Y.; Hirashima, Y.; Kato, K.; Nakajima, T.; Hamaguchi, T.; Shimada, Y. // Cancer Chemotherapy & Pharmacology;Feb2010, Vol. 65 Issue 3, p467 

    Bevacizumab (BV) prolongs the survival of colorectal cancer patients when combined with irinotecan (CPT-11)-based regimens. In the AVF2107g study, the area under the curve (AUC) ratio for bolus CPT-11/5-fluorouracil (5-FU)/leucovorin (LV) (IFL) with the BV arm to bolus IFL with placebo indicated...

  • Systemic Adverse Events after Intravitreal Bevacizumab versus Ranibizumab for Age-Related Macular Degeneration: A Meta-Analysis. Wang, Wei; Zhang, Xiulan // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Objective: To assess whether the incidence of systemic adverse events differs between those who used bevacizumab and those who used ranibizumab in the treatment of age-related macular degeneration (AMD). Methods: A systematic literature search was conducted to identify randomised controlled...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics