Gene mutations can produce polymorphisms that alter minimal daily micronutrient requirements

Herbert, Victor
February 2001
Clinical & Investigative Medicine;Feb2001, Vol. 24 Issue 1, p54
Academic Journal
Editorial. Offers observation on gene mutations which can produce polymorphisms that alter minimal daily micronutrient requirements. Information on an article about folate-utilizing enzyme methylenetetrahydrofolate reductase; Description on the protein produced by the autosomal recessive gene of hemochromatosis; Example of a gene mutation altering a protein involved in the transport and delivery of a micronutrient.


Related Articles

  • The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome. Santos-Rebouças, C. B.; CorrĂȘa, J. C.; Bonomo, A.; Fintelman-Rodrigues, N.; Moura, K. C. V.; Rodrigues, C. S. C.; Santos, J. M.; Pimentel, M. M. G. // Disease Markers;2008, Vol. 25 Issue 3, p149 

    Polymorphisms in genes encoding folate metabolizing enzymes have been linked to an increased risk of maternal chromosomal nondisjunction in several populations. With the purpose of evaluating this relationship, we compared the frequencies of 677C>T and 1298A>C polymorphisms in the...

  • Allelic Heterogeneity and Trade-Off Shape Natura Variation for Response to Soil Micronutrient. Kiani, Seifollah Poormohammad; Trontin, Charlotte; Andreatta, Matthew; Simon, Matthieu; Robert, Thierry; Salt, David E.; Loudet, Olivier // PLoS Genetics;Jul2012, Vol. 8 Issue 7, Special section p1 

    As sessile organisms, plants have to cope with diverse environmental constraints that may vary through time and space, eventually leading to changes in the phenotype of populations through fixation of adaptive genetic variation. To fully comprehend the mechanisms of evolution and make sense of...

  • How to re-energise old mitochondria without shooting yourself in the foot. Driver, Christopher; Georgiou, Angela // Biogerontology;Feb2002, Vol. 3 Issue 1/2, p103 

    In old humans and pathologies associated with mitochondrial mutations, deletions in mitochondrial DNA have been associated with failing function. Investigations have been reported where treatment with a number of micronutrients, such as coenzyme Q10, have been used to re-energise failing...

  • Correlation with Micronutrient Intake.  // Fertility Weekly;12/17/2012, p3 

    The article focuses on a study which reveals that sperm DNA damage is lower among men having higher dietary and supplement intake of specific micronutrients. It reveals that men age correlates with decreased semen quality as well as increased rates of sperm with structural aberrations and...

  • Genotoxicity of Tri- and Hexavalent Chromium Compounds In Vivo and Their Modes of Action on DNA Damage In Vitro. Fang, Zhijia; Zhao, Min; Zhen, Hong; Chen, Lifeng; Shi, Ping; Huang, Zhiwei // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Chromium occurs mostly in tri- and hexavalent states in the environment. Hexavalent chromium [Cr(VI)] compounds are extensively used in diverse industries, and trivalent chromium [Cr(III)] salts are used as micronutrients and dietary supplements. In the present work, we report that they both...

  • Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Mohammad, Naushad Shaik; Yedluri, Rupasree; Addepalli, Pavani; Gottumukkala, Suryanarayana Raju; Digumarti, Raghunadha Rao; Kutala, Vijay Kumar // Molecular & Cellular Biochemistry;Mar2011, Vol. 349 Issue 1/2, p159 

    The authors investigated the role of dietary micronutrients and eight functional polymorphisms of one-carbon metabolism in modulating oxidative stress in sporadic breast cancer. PCR-restriction fragment length polymorphism (RFLP) and PCR-amplified fragment length polymorphism (AFLP) methods were...

  • Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study. Sukla, K. K.; Jaiswal, S. K.; Rai, A. K.; Mishra, O. P.; Gupta, V.; Kumar, A.; Raman, R. // Human Reproduction;Aug2015, Vol. 30 Issue 8, p1982 

    STUDY QUESTION: Do gene-gene and gene-environment interactions in folate-homocysteine (Hcy) pathway have a predisposing role for Down syndrome (DS)? SUMMARY ANSWER: The study provides evidence that in addition to advanced age, maternal genotype, micronutrient deficiency and elevated Hcy levels,...

  • Screening for Genetic Mutations. A Review. Tawata, Masato; Aida, Kaoru; Onaya, Toshimasa // Combinatorial Chemistry & High Throughput Screening;Feb2000, Vol. 3 Issue 1, p1 

    A point mutation of a nucleotide within a single gene can have a profound effect on a specific organ and or the entire human body. DNA sequences associated with human diseases may differ from the corresponding normal sequences by single nucleotide mutations or by large alterations such as...

  • The amount of DNA polymorphism maintained in a finite population when the neutral mutation rate... Tajima, Fumio // Genetics;Jul96, Vol. 143 Issue 3, p1457 

    Examines the amount of DNA polymorphism maintained in a finite population when the neutral mutation rate varies among sites. Jukes and Cantor's model of mutation without rate variation; Equal-input model of mutation with rate variation; Kimura's model of mutation with rate variation.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics