Which Drug for the Pregnant Woman with Epilepsy?

Tomson, Torbj�rn
April 2009
New England Journal of Medicine;4/16/2009, Vol. 360 Issue 16, p1667
Academic Journal
The author discusses the challenges facing physicians in prescribing drugs that are effective in controlling seizures in women with epilepsy during pregnancy. It is argued that research on the teratogenicity of antiepileptic drugs has focused on anatomical birth defects, while little attention has been given to potential adverse effects on the cognitive development of children. The results of a study assessing the development of children exposed to anticonvulsant drugs in utero are assessed.


Related Articles

  • Characterization of the adverse events profile of placebo-treated patients in randomized controlled trials on drug-resistant focal epilepsies. Giovannelli, Fabio; Zaccara, Gaetano; Cincotta, Massimo; Loiacono, Giulia; Verrotti, Alberto // Journal of Neurology;Jun2015, Vol. 262 Issue 6, p1401 

    In epilepsy trials a substantial proportion of patients receiving placebo has some improvement or experience adverse events (AEs) which match those related to active drug. The characterization of factors influencing these responses is crucial for a better comprehension of study results and to...

  • Anticonvulsant therapy in the elderly--a need for placebo controlled trials? Cameron, H.J.; Reid, W. // Age & Ageing;Jan1994, Vol. 23 Issue 1, British Geriatrics... pP17 

    Analyzes the long-term clinical course and response to anticonvulsant treatment of epileptic seizures in the elderly. Study fo patients with a mean age of 73 years with a definite diagnosis of seizures; Etiology of the seizures; Treatment modalities; Association between anticonvulsant treatment...

  • Fetal sodium vaiproate exposure causes Baller-Gerold syndrome phenotype: both phenotypes in the same family. Özdemir, Özmert M. A.; Kılıç, İlknur; Özsarı, Tamer; Kılıç, B. Alper; Faivre, Laurence; Aral, Bernard; Gürses, Dolunay; Semerci, C. Nur // Turkish Journal of Pediatrics;Nov/Dec2009, Vol. 51 Issue 6, p631 

    Baller-Gerold syndrome (BGS) is characterized by craniosynostosis and pre-axial upper-limb malformations, and it has an autosomal recessive inheritance. Valproate syndrome occurs after exposure to vaiproic acid in utero, and is characterized by trigonocephaly. Both syndromes can also present...

  • Drug-induced gingival overgrowth: The nemesis of gingiva unravelled. Bharti, Vipin; Bansal, Chhaya // Journal of Indian Society of Periodontology;Mar-Apr2013, Vol. 17 Issue 2, p182 

    Drug-induced gingival overgrowth or enlargement manifests as abnormal growth of the gingiva due to an adverse drug reaction (ADR) in patients treated with anticonvulsants, immunosuppressants, and calcium channel blockers. As gingival enlargement develops, it affects the normal oral hygiene...

  • Retrospective analysis of Steven Johnson syndrome and toxic epidermal necrolysis over a period of 5 years from northern Karnataka, India. Naveen, Kikkeri Narayanasetty; Pai, Varadraj V.; Rai, Vijetha; Athanikar, Sharatchandra B. // Indian Journal of Pharmacology;Jan/Feb2013, Vol. 45 Issue 1, p80 

    Objective: Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal...

  • The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics. Moghimi, Ali; Mollazadeh, Samaneh; Rassouli, Fatemeh Behnam; Shiee, Reza; Khalilzade, Mohammad Ali // Basic & Clinical Neuroscience;Winter2013, Vol. 4 Issue 1, p31 

    Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental...

  • Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. Khairkar, Praveen; Gupta, Neha; Varma, Sushil Kumar // Indian Journal of Pharmacology;Jan/Feb2013, Vol. 45 Issue 1, p95 

    Adverse effects to antipsychotics are varied, frequently intolerable, often serious and sometimes fatal in clinical practice. Seizures are one of these adverse effects. Almost all first and second generation antipsychotics elicit dose-dependent lowering of seizure threshold, indicating increased...

  • Ethosuximide.  // Reactions Weekly;02/09/2013, Issue 1438, p15 

    The article presents a case study of a 11-year-old girl who developed Rolandic electroencephalographic (EEG) spikes while undergoing ethosuximide treatment for absence seizures.

  • Clinical digest. Long-term use of older antiepileptic drugs can lead to hardening of the arteries.  // Nursing Standard;12/7/2011, Vol. 26 Issue 14, p16 

    The article reports on research on epilepsy treatment which was featured in a 2011 issue of "Epilepsia" and found that long-term use of some varieties of an older generation of antiepileptic drugs increases the risk of developing atherosclerosis.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics