Chronic microinflammation and endothelial damage in uremia

Ojeda, R.; Aljama, P. A.
December 2008
Nefrologia;Dec2008, Vol. 28 Issue 6, p583
Academic Journal
The article presents information on the role of chronic microinflammation state in uremia in the development of endothelial damage in patients with chronic kidney disease (CKD). Endothelial cells are damaged by reactive oxygen species (ROS) which gets released due to the imbalance between pro-inflammatory and anti-inflammatory mechanisms which occur in patients with uremia. Increase in the level of asymmetric dimethylarginine (ADMA) also influences the development of endothelial damage.


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