Epigenetic changes wipe out protective mechanisms in Barrett's oesophagus

Fitzgerald, Rebecca C.
January 2009
Gut;Jan2009, Vol. 58 Issue 1, p1
Academic Journal
The author reflects on the effect of epigenetic changes in Barrett's oesophagus. The author relates that reactive oxygen and nitrogen species play important roles in the regulation of cell survival. The effects are dose dependent and consist of two states which include reversible redox regulation and irreversible oxidative molecular damage. She added that the Barrett's oesophageal epithelium is bathed in a hostile luminal environment comprising reflux and dietary components.


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