Mutations in a Molecule: The Virtues of Antagonism

Kharasch, Evan D.
October 2008
Mayo Clinic Proceedings;Oct2008, Vol. 83 Issue 10, p1083
Academic Journal
The author reflects on mutations in a molecule and the virtues of antagonism in clinical trials. He notes that drug development evolved through eras of natural product use, serendipitous discovery, national drug design and drug discovery. He found the discovery and development stories of methyl-naltrexone and alvimopan fascinating and provide an interesting perspective on modern drug development.


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