Beware of Over-Interpreting Negative Trials

Scahill, Lawrence; Aman, Michael G.; McCracken, James T.; McDougle, Christopher J.; Vitiello, Benedetto
October 2008
Journal of Autism & Developmental Disorders;Oct2008, Vol. 38 Issue 9, p1609
Academic Journal
The article focuses on the pragmatic trial which addresses a problem of clinical decision-making. In its pure form, a pragmatic trial would compare two evidence-based treatments to help clinicians in selecting which one should be selected first. By contrast, an efficacy trial is designed to determine whether a treatment is effective.


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