Role of gastric atrophy in mediating negative association between Helicobacter pylon infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma

McColl, Kenneth E. L.; Watabe, Hirotsugu; Derakhshan, Mohammad H.
June 2008
Gut;Jun2008, Vol. 57 Issue 6, p721
Academic Journal
The author comments on the role of gastric atrophy in the negative association between Barrett's esophagus and esophageal adenocarcinoma, and Helicobacter pylori infection and reflux esophagitis. An assumption that the protective effect is due to the infection inducing gastric atrophy and is being associated with increased risk of gastric adenocarcinoma. Meanwhile, Helicobacter pylori infection does not produce detectable atrophy and protects against esophageal adenocarcinoma.


Related Articles

  • Re: Incidence of Adenocarcinoma of the Esophagus Among White Americans by Sex, Stage, and Age. CHUN-RU CHIEN; CHEN-YUAN LIN; CHIH-YI CHEN // JNCI: Journal of the National Cancer Institute;10/21/2009, Vol. 101 Issue 20, p1428 

    The article comments on a study dealing with the incidence of adenocarcinoma of the esophagus in the Western world. It is reported that one the main problem in the U.S. is obesity which leads to increase in intra-abdominal pressure with ensuing gastroesophagaeal reflux disease and Barrett's...

  • The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan. Koike, T.; Ohara, S.; Inomata, Y.; Abe, Y.; Iijima, K.; Shimosegawa, T. // Inflammopharmacology;Apr2007, Vol. 15 Issue 2, p61 

    We have previously reported that H. pylori infection prevents reflux esophagitis (RE) and Barrett’s esophagus (BE) by decreasing gastric acid secretion. Gastroesophageal (GE) junction adenocarcinoma, including Barrett’s adenocarcinoma, has been thought to be a complication of...

  • H. pylori infection less common among patients with Barrett's esophagus.  // Hem/Onc Today;6/25/2013, Vol. 14 Issue 12, p70 

    The article discusses research by Assistant Professor Joel H. Rubenstein and colleagues at the University of Michigan Medical School which revealed the association of Barrett's esophagus and erosive esophagitis with Helicobacter pylori infection.

  • Barrett's Esophagus in an Area with an Exceptionally Low Prevalence of Helicobacterpylori Infection. Yeong Yeh Lee; Sharif, Sharifah Emilia Tuan; Aziz, Syed Hassan Syed Abd; Raj, S. Mahendra // ISRN Gastroenterology;2011, Special section p1 

    Objective. This study was undertaken to gain an insight into the relationship between Helicobacter pylori (H pylori) infection, Barrett's esophagus and reflux esophagitis in an area of exceptionally low prevalence of H. pylori infection. Methods. A total of 1895 consecutive upper endoscopies...

  • Prevalence of Barrett's esophagus in Northern Greece: A Prospective Study (Barrett's esophagus). Katsinelos, P.; Lazaraki, G.; Kountouras, J.; Chatzimavroudis, G.; Zavos, C.; Terzoudis, S.; Tsiaousi, E.; Gkagkalis, S.; Trakatelli, C.; Bellou, A.; Vasiliadis, T. // Hippokratia;2013, Vol. 17 Issue 1, p27 

    Background: Barrett's esophagus(BE) is a premalignant condition associated with chronic gastro-esophageal reflux disease (GERD). As only a small proportion of BE progresses to malignancy, it is important to study BE prevalence to prevent adenocarcinoma. Materials and Methods: Between January...

  • Helicobacter pylon infection and the risk of Barrett's oesophagus: a community-based study. Corley, D. A.; Kubo, A.; Levin, T. R.; Block, G.; Habel, L.; Zhao, W.; Leighton, P.; Rumore, G.; Quesenberry, C.; Buffler, P.; Parsonnet, J. // Gut;Jun2008, Vol. 57 Issue 6, p727 

    Objective: Gastric colonisation with the Helicobacter pylori bacterium is a proposed protective factor against oesophageal adenocarcinoma, but its point of action is unknown. Its associations with Barrett's oesophagus, a metaplastic change that is a probable early event in the carcinogenesis of...

  • Proton pump inhibitors: the culprit for Barrett's esophagus? Alsalahi, Omran; Dobrian, Anca D. // Frontiers in Oncology;Jan2015, Vol. 5, p1 

    The article discusses the role of Proton pump inhibitors (PPI) in Barrett's esophagus (BE), a condition that involves intestinal metaplasia of the stratified squamous epithelium of distal esophagus. Topics include gastroesophageal reflux disease (GERD) and its treatment and management, role of...

  • JournalScan.  // Gut;Feb2004, Vol. 53 Issue 2, p314 

    The article presents several abstracts related to Helicobacter pylori eradication. The abstract "Viral and Clinical Factors Associated With the Fulminant Course of Hepatitis A Infection," by G. Rezende, A.M. Roque-Afonso and D. Samuel was published in the 2003 issue of "Hepatology." It discusses...

  • Helicobacter pylori Extract Induces Nuclear Factor-kappa B, Activator Protein-1, and Cyclooxygenase-2 in Esophageal Epithelial Cells Abdel-Latif, Mohamed M.M.; Windle, Henry; Terres, Ana; Eidhin, Déirdre Ní; Kelleher, Dermot; Reynolds, John V.; Eidhin, Déirdre Ní // Journal of Gastrointestinal Surgery;Apr2006, Vol. 10 Issue 4, p551 

    Helicobacter pylori infection is recognized as the major cause of gastritis and gastric cancer; however, its role in the development of gastroesophageal reflux disease and Barrett''s adenocarcinoma is unclear. The expression of NF-κB, AP-1, and COX-2 may be important in inflammation and...


Read the Article


Sign out of this library

Other Topics