Assessing the safety of drugs through observational research

Simpson Jr., Ross J.
February 2008
Heart;Feb2008, Vol. 94 Issue 2, p129
Academic Journal
The author reflects on the safety of digitalis which is the oldest drug still being used by clinicians. He pointed out that the observational research which suggests that digitalis increases mortality in patients with chronic atrial fibrillation is prone to bias because adverse outcomes are attributed to the drug and not to the clinical condition for which the drug was prescribed. He suggests that large observational studies are ideal for assessing the toxicity of digitalis.


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