Predicting the development of hepatocellular cancer in hepatitis B carriers

de Mitri, M.S.; Bernardi, M.
January 2008
Gut;Jan2008, Vol. 57 Issue 1, p12
Academic Journal
The article reflects on predicting hepatocellular cancer (HCC) development in hepatitis B virus (HBV) carriers. Association between cirrhosis and CC suggests that increased liver cell turnover caused by chronic liver injury and regeneration is the common pathway for hepatocarcinogenesis. Another probability is that HBV-induced HCC resulted from a combination of different interacting effects like integration of HBV DNA and viral proteins, and others.


Related Articles

  • Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer Il/core promoter/precore regions and HBV DNA levels. Yuen, M-F; Tanaka, Y.; Shinkai, N.; Poon, R. T.; But, D. Yiu-Kuen; Fong, D Y-T; Fung, J; Ka-Ho Wang, D; Chi-Hang Yuen, J; Mizokami, M; Lai, C-L // Gut;Jan2008, Vol. 57 Issue 1, p98 

    Background/aim: To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. Methods: HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248...

  • Reasons to consider earlier treatment of chronic HBV infections. Zoulim, Fabien; Mason, William S. // Gut;Mar2012, Vol. 61 Issue 3, p333 

    The article discusses the reasons to consider earlier for the treatment of chronic hepatitis B virus (HBV) infections. It states that cirrhosis, liver failure and hepatocellular carcinoma (HCC) diseases are caused by the HBV infection which occur at the early stage of life. It also informs that...

  • Lack of Correlation Between Serum Anti-HBcore Detectability and Hepatocellular Carcinoma in Patients With HCV-Related Cirrhosis. Stroffolini, Tommaso; Almasio, Piero Luigi; Persico, Marcello; Bollani, Simona; Benvegn, Luisa; Di Costanzo, GiovanGiuseppe; Pastore, Giuseppe; Aghemo, Alessio; Stornaiuolo, Gianfranca; Mangia, Alessandra; Andreone, Pietro; Stanzione, Maria; Mazzella, Giuseppe; Saracco, Giorgio; Del Poggio, Paolo; Bruno, Savino // American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p1966 

    BACKGROUND: While the likelihood of developing hepatocellular carcinoma (HCC) in patients coinfected with both HBV and HCV is increased, the role of previous exposure to HBV as a risk factor associated with tumor occurrence in subjects with HCV-related cirrhosis has not been fully investigated....

  • Histological characteristics predisposing to development of hepatocellular carcinoma in patients with chronic hepatitis B. Sae Hwan Lee; Young-Hwa Chung; Kim, Jeong A.; Young-Joo Jin; Won Hyung Park; Jong Gi Choi; Danbi Lee; Ju Hyun Shim; Eunsil Yu; Myoung Kuk Jang // Journal of Clinical Pathology;Jun2011, Vol. 64 Issue 6, p599 

    Aims Longstanding liver inflammation leads to hepatic regeneration and fibrosis, which subsequently progresses to cirrhosis in some patients with chronic hepatitis B virus (HBV) infection. It remains unclear, however, if the histological severity of chronic hepatitis B (CHB) may determine the...

  • Radiological Study of Idiopathic Budd-Chiari Syndrome Complicated by Hepatocellular Carcinoma. A Report of Four Cases. Takayasu, Kenichi; Muramatsu, Yukio; Moriyama, Noriyuki; Wakao, Fumihiko; Makuuchi, Masatoshi; Takayama, Tadatoshi; Kosuge, Tomoo; Okazaki, Nobuo; Yamada, Ryusaku // American Journal of Gastroenterology;Feb1994, Vol. 89 Issue 2, p249 

    During an 11-yr period (1979-1989), we have experienced five patients with idiopathic Budd-Chiari syndrome (BCS), four (80%) of whom had associated hepatocellular carcinoma (HCC). In contrast, the incidence of BCS complicated by HCC was 0.7% of a total of 556 patients who underwent surgery for...

  • Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells. Sokolowska, Izabela; Dorobantu, Cristina; Woods, Alisa G.; Macovei, Alina; Branza-Nichita, Norica; Darie, Costel C. // Proteome Science;2012, Vol. 10 Issue 1, p47 

    Liver infection with hepatitis B virus (HBV), a DNA virus of the Hepadnaviridae family, leads to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps of the viral life cycle are largely obscure and the host cell plasma membrane receptors are not known. HepaRG...

  • Genome-wide association study of chronic hepatitis B virus infection reveals a novel candidate risk allele on 11q22.3. Al-Qahtani, Ahmed; Khalak, Hanif G.; Alkuraya, Fowzan S.; Al-hamoudy, Waleed; Alswat, Khalid; Al Balwi, Mohammed A.; AbdulKareem, Ibrahim Al; Sanai, Faisal M.; Abdo, Ayman A. // Journal of Medical Genetics;Nov2013, Vol. 50 Issue 11, p725 

    Background Hepatitis B virus (HBV) affects millions of people worldwide. While some people are able to clear the virus following the first encounter, those who develop chronic infection manifest remarkable clinical heterogeneity that ranges from asymptomatic carrier state to cirrhosis and...

  • Nutritional Status in Cirrhotic Patients. TEIUSANU, Adriana; ANDREI, Mihai; ARBANAS, Tudor; NICOLAIE, Tudor; DICULESCU, Mircea // Romanian Journal of Medical Practice;2012, Vol. 7 Issue 4, p284 

    Background: Malnutrition is prevalent in all forms of liver disease: from 20% in compensated liver disease to more than 80% in those patients with decompensated liver disease. Protein-calorie malnutrition (PCM) can be identified in all clinical stages but is easier observed in advanced stages of...

  • Direct economic burden of hepatitis B virus related diseases: evidence from Shandong, China. Jingjing Lu; Aiqiang Xu; Jian Wang; Li Zhang; Lizhi Song; Renpeng Li; Shunxiang Zhang; Guihua Zhuang; Mingshan Lu // BMC Health Services Research;2013, Vol. 13 Issue 1, p1 

    Background: Although the expenses of liver cirrhosis are covered by a critical illness fund under the current health insurance program in China, the economic burden associated with hepatitis B virus (HBV) related diseases is not well addressed. In order to provide evidence to address the...


Read the Article


Sign out of this library

Other Topics