COMMENTARY: Lansoprazole was not effective in young dyspeptic patients without Helicobacter pylori

Talley, Nicholas J.
January 2008
ACP Journal Club;Jan/Feb2008, Vol. 148 Issue 1, p10
Academic Journal
The author comments on the study which examines the effect of lansoprazole in treating dyspepsia without Helicobacter pylori. Study shows that lansoprazole did not reduce dyspepsia or enhance quality of life in the patients without Helicobacter pylori. The author indicates that high rates of unrecognized gastroesophageal reflux disease probably account for the response to acid suppression.


Related Articles

  • Lansoprazole was not effective in young dyspeptic patients without Helicobacter pylori.  // ACP Journal Club;Jan/Feb2008, Vol. 148 Issue 1, p10 

    The article presents a study which examines the effect of lansoprazole in treating dyspepsia without Helicobacter pylori. Here, the researchers use randomized placebo-controlled trial for the young dyspeptic patients. Study shows that lansoprazole did not reduce dyspepsia or enhance quality of...

  • Successful H. pylori eradication ups QOL in functional dyspepsia.  // PharmacoEconomics & Outcomes News;12/17/2005, Issue 493, p17 

    The article focuses on a study on the role of successful Helicobacter pylori eradication in improving the quality of life in patients with functional dyspepsia, particularly those patients with ulcer-like and dysmotility-like dyspepsia. It describes a standard eradication triple therapy with...

  • Patterns of Symptoms in Functional Dyspepsia: Role of Helicobacter pylori Infection and Delayed Gastric Emptying. Perri, Francesco; Clemente, Rocco; Festa, Virginia; Annese, Vito; Quitadamo, Michele; Rutgeerts, Paul; Andriulli, Angelo // American Journal of Gastroenterology;Nov1998, Vol. 93 Issue 11, p2082 

    Objective: Functional dyspepsia (FD) is a syndrome in which several causes are probably involved. Our aim was to investigate the association between specific dyspeptic symptoms and Helicobacter pylori infection or delayed gastric emptying. Methods: Nine hundred thirty-five consecutive...

  • One-day drug regimen for H pylori is effective. Polak, Monika // GP: General Practitioner;10/13/2003, p4 

    One-day quadruple therapy for Helicobacter pylori is as effective as the standard seven-day triple drug regimen, according to a U.S. research. Researchers randomly assigned 160 patients with dyspepsia, who had a positive urea breath test, to one of two groups. The researchers found that both...

  • Formulary management of proton pump inhibitors. Byrne, M.F.; Murray, F.E. // PharmacoEconomics;1999, Vol. 16 Issue 3, p225 

    The management of dyspepsia has been radically altered by the discovery of the role of Helicobacter pylori and the advent of proton pump inhibitors (PPIs). The use of PPIs alone as antisecretory agents and as part of triple therapy regimens for H. pylori eradication accounts for a significant...

  • Confusion grows on H.pylori -GORD link.  // Pulse;1/26/2004, Vol. 64 Issue 4, p15 

    Reports on the study published in the January 2004 issue of the "Gut" journal which concludes that Helicobacter pylori eradication therapy should be prescribed for gastro-oesopgaeal reflux disease (GORD) patients. Reaction of Kenneth McColl, professor of medicine at the University of Glasgow in...

  • Lack of Effect of Treating. Blum, André L.; Talley, Nicholas J.; O'Moráin, Colm; van Zanten, Sander Veldhuyzen; Labenz, Joachim; Stolte, Manfred; Louw, Japie A.; Stubberöd, Arild; Theodórs, Asgeir; Sundin, Marie; Bolling-Sternevald, Elisabeth; Junghard, Ola // New England Journal of Medicine;12/24/98, Vol. 339 Issue 26, p1875 

    Background: It is uncertain whether treatment of Helicobacter pylori infection relieves symptoms in patients with nonulcer, or functional, dyspepsia. Methods: We conducted a double-blind, multicenter trial of patients with H. pylori infection and dyspeptic symptoms (moderate-to-very-severe pain...

  • Editorial: Dyspepsia, Peptic Ulcer, and H. pylori: A Remembrance of Things Past. Vakil, Nimish // American Journal of Gastroenterology;Mar2010, Vol. 105 Issue 3, p572 

    Abstract: Dyspepsia and gastroesophageal reflux disease are common conditions in clinical practice. Current management strategies emphasize testing and treatment for Helicobacter pylori in the initial management of patients presenting with dyspeptic symptoms in regions where the prevalence of H....

  • Symptomatic Benefit 1-3 Years After H. pylori Eradication in Ulcer Patients: Impact of Gastroesophageal Reflux Disease. McColl, Kenneth E. L.; Dickson, Anthea; El-Nujumi, Adil; El-Omar, Emad; Kelman, Andrew // American Journal of Gastroenterology;Jan2000, Vol. 95 Issue 1, p101 

    OBJECTIVES: Eradication of Helicobacter pylori (H. pylori) infection markedly reduces the recurrence of duodenal and gastric ulcers. However, there is little information regarding its efficacy in resolving dyspeptic symptoms in ulcer patients. The primary aim of this study was to assess...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics