New tests for tuberculosis: local immune responses have greater specificity

Bothamley, Graham H.
January 2008
Thorax;Jan2008, Vol. 63 Issue 1, p4
Academic Journal
The author analyzes two studies on new tests for tuberculosis that use early secretory antigen target-6 (ESAT-6) in the CD4+ T cell response (ESAT-6) and culture filtrate protein-10 (CFP-10) antigens found in region of difference 1 (RD1), which is deleted in BCG but found in all pathogenic strains of Mycobacterium tuberculosis complex. The studies analyzed bronchoalveolar lavage (BAL) cells in patients with suspected but smear-negative pulmonary tuberculosis.


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