CIMP and colon cancer gets more complicated

Grady, William M.
November 2007
Gut;Nov2007, Vol. 56 Issue 11, p1498
Academic Journal
The article presents the author's comments related to the formation of colon cancers (CRC) in adults due to the cumulative effect of inherited genetic susceptibilities and environmental exposure. As per stated, CRC can be divided into two molecular categories called chromosome instability group and microsatellite instability group. As per stated, CpG island methylation is the main factor in CRC formation as it silences the expression of tumor suppressor genes.


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