Indication creep: physician beware
- Off-label use of erythropoietin may be harmful, doctors told. Spurgeon, David // BMJ: British Medical Journal (International Edition);9/15/2007, Vol. 335 Issue 7619, p532
This article reports on a caution issued by the Canadian Medical Association (CMA) on the off-label use of erythropoietin to treat anaemia in critically ill patients. The CMA says the caution is based on a meta-analysis in its journal which suggests that treatment of patients on dialysis, those...
- Epidemiology of severe sepsis in the intensive care unit. Vincent, Jean-Louis; Atalan, Hakan Korkut // British Journal of Hospital Medicine (17508460);Aug2008, Vol. 69 Issue 8, p442
The article examines the various studies on epidemiology of severe sepsis in the intensive care unit (ICU). Two key considerations in reviewing the published epidemiological data of sepsis in the ICU are presented, including admission and length of stay, and the scope size of the study....
- Gastrointestinal Complications in Critically Ill Patients: The Intensivists' Overview. Gottlieb, Jonathan E.; Menashe, Phillip I.; Cruz, Edwin // American Journal of Gastroenterology;Apr1986, Vol. 81 Issue 4, p227
The critical care environment may be characterized by invasive monitoring, vasoactive drugs, and major interventions which may have adverse effects on gastrointestinal function. Furthermore, conditions such as heart failure or sepsis may compromise oxygen delivery to gastrointestinal organs....
- Focus on optimization of early antimicrobial therapy in ICU-acquired infections. Timsit, Jean-François; Paiva, José-Artur; Bassetti, Matteo; Timsit, Jean-François; Paiva, José-Artur // Intensive Care Medicine;Nov2016, Vol. 42 Issue 11, p1658
The article focuses on the optimization of antimicrobial therapy in intensive care unit-acquired infections. Topics include an overview on the development of antimicrobial therapy which seeks to deliver appropriating medical treatment while limiting antibiotic selection pressure and resistance,...
- Influenza treatment with oseltamivir outside of labeled recommendations. MCQUADE, BRIANNA; BLAIR, MELISSA // American Journal of Health-System Pharmacy;1/15/2015, Vol. 72 Issue 2, p112
Purpose: Published evidence regarding the use of the antiinfluenza agent oseltamivir outside of the standard dosing recommendations is reviewed. Summary: Oseltamivir is a neuraminidase inhibitor indicated for the treatment of uncomplicated influenza in patients two weeks of age or older who have...
- CME/CNE Questions. // Critical Care Alert;Dec2007, Vol. 15 Issue 9, p71
A quiz about the administration of erythropoietin to critically ill patients is presented.
- Speak Out. Wright, David; Avallone, Anthony N.; Berger, Aaron; Wrenn, John // Urology Times;4/1/2009, Vol. 37 Issue 4, p30
The article presents answers to a question on whether pharmaceutical companies be allowed to market pharmaceutical products for off-label use.
- Off-Label Drug Uses. . Generali, Joyce A.; Cada, Dennis J. // Hospital Pharmacy;Mar2010, Vol. 45 Issue 3, p208
This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a quarterly publication available from Wolters Kluwer Health. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. This...
- SLEEPING PILLS. Hanau, Michael S. // Primary Psychiatry;May2008, Vol. 15 Issue 5, p23
A letter to the editor is presented in response to an article by Milton K. Erman which critiques the popularity of trazodone and other non-benzodiazepine analogs for off-label use.