Vitamin B12, Folic Acid, and the Prevention of Dementia

Clarke, Robert
June 2006
New England Journal of Medicine;6/29/2006, Vol. 354 Issue 26, p2817
Academic Journal
The author discusses the link between Vitamin B12, folic acid and the prevention of dementia. He describes the prevalence of dementia in the U.S. He details a study which examined the effects of homocysteine-lowering vitamin supplements on the on cognitive function of healthy elderly people. The author noted that Vitamin B12 is an effective determinant of elevated homocysteine concentrations in older people than folate.


Related Articles

  • Role of vitamin B12, folate, and thyroid stimulating hormone in dementia: A hospital-based study in north Indian population. Agarwal, Rachna; Chhillar, Neelam; Kushwaha, Suman; Singh, Neeraj Kumar; Tripathi, Chandra Bhushan // Annals of Indian Academy of Neurology;Oct-Dec2010, Vol. 13 Issue 4, p257 

    Background: Vitamin B12 and folate represent modifiable risk factors for dementia. They may increase the risk of Alzheimer's dementia (AD) and vascular dementia (VaD) as their deficiency can increase the homocysteine level due to slowed methylation reaction. Homocysteine has a neurotoxic effect...

  • Cobalamin and Folate Status in 6 to 35 Months Old Children Presenting with Acute Diarrhea in Bhaktapur, Nepal. Ulak, Manjeswori; Chandyo, Ram K.; Adhikari, Ramesh K.; Sharma, Pushpa R.; Sommerfelt, Halvor; Refsum, Helga; Strand, Tor A. // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Background: Cobalamin and folate are essential micronutrients and are important in DNA and RNA synthesis, cell proliferation, growth, hematopoiesis, and cognitive function. However, data on cobalamin and folate status are lacking particularly from young children residing in low and middle income...

  • Dementia/Higher function disorders.  // Journal of Neurology;May2006 Supplement 2, Vol. 253, pII70 

    The article presents abstracts of medical research related to dementia and higher function disorders. They include "The burden experienced by caregivers of patients with Alzheimer's disease and related dementias," "Are normals entirely normal in tests of executive function?," and "Vitamin B12...

  • Predicting Estimates of Premorbid Memory Functioning: Validation in a Dementia Sample. Duff, Kevin; Chelune, Gordon J.; Dennett, Kathryn // Archives of Clinical Neuropsychology;Dec2011, Vol. 26 Issue 8, p701 

    Formulae to estimate premorbid memory functioning in a sample of cognitively intact older adults have been developed. These formulae were validated in a small sample of patients with amnestic Mild Cognitive Impairment. However, further validation is clearly needed. The current study applied...

  • No connection for B supplements and improved cognitive function.  // Geriatrics;Mar2007, Vol. 62 Issue 3, p13 

    The article provides information on the results of the research "Vitamin B6, B12 and Folic Acid Supplementation and Cognitive Function: A Systematic Review of Randomized Trials," conducted by physician Ethan Balk and colleagues. It was found that oral supplements may become unsuccessful in...

  • Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer's Disease. Karimi, Fariba; Haghighi, Afshin Borhani; Petramfar, Payman // Iranian Journal of Medical Sciences;Sep2009, Vol. 34 Issue 3, p181 

    Background: Alzheimer's disease is the most common form of dementia in the elderly. Serum levels of homocysteine have been related to increased cortical and hippocampal atrophy. We aimed to determine the serum levels of homocysteine, folate, and vitamin B12 in patients with Alzheimer's disease....

  • Plasma Homocysteine level is independently associated with rates of cognitive decline. Narayan, S. K.; Saxby, B.; Firbank, M. J.; O'Brien, J. T.; McKeith, I.; Gray, J. C.; Ford, G. // Annals of Indian Academy of Neurology;2007 Supplement 2, Vol. 10, p48 

    Background: Plasma Homocysteine levels have been associated with cognitive decline and dementia in several case-control and prospective studies through cross-sectional methods. However its association with the rates of cognitive decline remains yet to be studied. Aim: To investigate for any...

  • Brain food. Matthews, Robert // New Scientist;10/24/98, Vol. 160 Issue 2157, p12 

    Focuses on a study that suggests that boosting your intake of vitamin B12 and folates could help stave off Alzheimer's disease. Results of analysis of blood samples taken in a 1988 Optima study; Factors which had a common link; Possible demand to pressure governments to add folic acid...

  • Folic acid, ageing, depression, and dementia. Reynolds, E H // BMJ: British Medical Journal (International Edition);6/22/2002, Vol. 324 Issue 7352, p1512 

    Reviews evidence relating folate deficiency to depression and dementia, especially in the aging nervous system. Topics of epileptic, neurological, psychiatric, and geriatric and psychogeriatric patients; Neuropsychological and neuropathological studies; Neurochemical aspects of folates in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics