COMMENTARY: Etoricoxib was noninferior to diclofenac for cardiovascular outcomes in osteoarthritis and rheumatoid arthitis

Denman, Michael
March 2007
ACP Journal Club;Mar/Apr2007, Vol. 146 Issue 2, p44
Academic Journal
The article presents the comments of the author about a study which states that etoricoxib was noninferior to diclofenac for cardiovascular (CV) outcomes in osteoarthritis and rheumatoid arthitis. The efficacy and incidence of adverse CV and gastrointestinal events were oberved in patients receiving etoricoxib or diclofenac. This large-scale and immaculately designed and executed trial showed that the incidence of major CV events was similar in both groups.


Related Articles

  • Etoricoxib results in fewer upper GI events compared with diclofenac users according to MEDAL program.  // Formulary;May2007, Vol. 42 Issue 5, p312 

    The article reports on the effectiveness of etoricoxib over another nonsteroidal anti-inflammatory agent diclofenac in limiting upper gastrointestinal (GI) events in patients with osteoarthritis or rheumatoid arthritis. The said finding was derived from a safety analysis of the Multinational...

  • Diclofenac/Misoprostol. Plosker, Greg L.; Lamb, Harriet M. // PharmacoEconomics;1999, Vol. 16 Issue 1, p85 

    â–´ The combined formulation of diclofenac/misoprostol provides effective relief of pain and inflammation, with a 2- to 3-fold lower incidence of NSAID-associated gastroduodenal ulcers than diclofenac monotherapy. â–´ Both components of the combined formulation have been widely used and...

  • Crystal arthritis. Gorevic, Peter D.; Sherman, Fredrick T.; Cassetta, Michael // Geriatrics;Sep2004, Vol. 59 Issue 9, p25 

    Gout and pseudogout are inflammatory arthritides due to monosodium urate and calcium pyrophosphate dihydrate crystal formation. Both are prevaient among geriatric patients, and can present as acute mono- or oligoarticular disease, or as a chronic polyarthropathy resembling osteoarthritis or...

  • Comparing celecoxib with traditional nonsteroidal anti-inflammatory drugs. Johnson, Melissa; Seaton, Terry // Journal of Family Practice;Feb2003, Vol. 52 Issue 2, p96 

    The article presents a study comparing the efficacy, safety and tolerability of celecoxib with other nonsteroidal anti-inflammatory drugs (NSAID) for treating osteoarthritis or rheumatoid arthritis. Celecoxib was developed to provide symptom relief without the NSAID-associated gastrointestinal...

  • Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. Whelton, A.; Lefkowith, J. L.; West, C. R.; Verburg, K. M. // Kidney International;Oct2006, Vol. 70 Issue 8, p1495 

    The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in...

  • Multicentre trial in people with arthritis finds increased risk of clinically significant gastrointestinal events with diclofenac plus omeprazole compared with celecoxib. Rostom, Alaa // Evidence Based Medicine;Aug2011, Vol. 16 Issue 4, p110 

    The author comments on the study "Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial," published in a 2010 issue of "Lancet." He notes that the current study provided a formalised definition of an upper and lower...

  • Diclofenac.  // AHFS Consumer Medication Information;Sep2016, p1 

    Diclofenac is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly...

  • Diclofenac.  // Reactions Weekly;7/8/2006, Issue 1109, p9 

    The article presents a medical case of a 65-year-old woman who had rheumatoid arthritis, developed colonic structures and perforation during treatment with long-term diclofenac. The woman developed infectious arthritis and underwent surgical wash out of her joint. Pathology of her resected...

  • PREDICTORS OF THE USE OF GASTROPROTECTIVE AGENTS IN PATIENTS USING NSAID IN YOGYAKARTA INDONESIA. Indrianto, Ady Bagus; Thobari, Jarir At; Nugroho, Agung Endro // Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia;Mar2012, Vol. 23 Issue 1, p41 

    Non Steroid Anti-Inflammatory (NSAID) is one type of Anti- Inflammatory drug that is used to treat pain in patients of osteoarthritis (OA) and rheumatoid arthritis (RA). The use of NSAIDs can cause gastrointestinal side effects. To prevent the side effects, NSAIDs are prescribed in combination...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics